Release notes

Rsmlx 2024.1 – (on GitHub, June 10th 2024)

• Made the package compatible with 2024R1 version of MonolixSuite

• Added error in the case of version mismatch among Rsmlx, lixoftConnectors, and MonolixSuite

• Fixed bugs related to launched tasks in buildmlx, warning in pkpopini, and error in buildVar in some cases

• Handle nbSSDoses in bootmlx

Rsmlx 2023.1.2 – (on GitHub, August 10th 2023)

• Added a more informative error message in case of data set headers not matching Monolix headers when using bootmlx

• Fixed a bug in bootmlx causing data set generation getting stuck in certain cases when using projects with occasions and covStrat

Rsmlx 2023.1.1 – (on GitHub and CRAN, June 19th 2023)

• Renamed two helper functions to pass CRAN checks

Rsmlx 2023.1 – (on GitHub, May 30th 2023)

• Made the package compatible with 2023R1 version of MonolixSuite

• Refactored bootmlx code to handle replicates one by one

  • bootmlx now generates data sets and Monolix projects just before running parameter estimation, instead of generating all data sets before estimating parameters for all replicates

  • it is now possible to delete generated data sets and projects using the additional arguments

• Fixed a bug when running bootstrap on a project that contains unmapped variables that can be mapped to observation IDs (generated projects would have those variables automatically mapped)

• Running bootmlx on a project with data set that contains special characters returns a more meaningful error

Rsmlx 5.0.1 – (on GitHub and CRAN, June 15th, 2022).

• It is now possible to introduce some prior information about the statistical model in buildmlxand buildAll.

• Additional tests can be performed (or not) for building the statistical model using buildmlx or buildAll and the SAMBA algorithm.

• Different criteria can be used for building the PK model with pkbuild,as well as the possibility to linearize (or not) model for computing the likelihood

• Several bugs have been fixed.

Rsmlx 4.0.3 – (on GitHub, March 11th, 2022).

• An error occurred with bootmlx using R Studio 2022

• Using buildAll, package lixoftConnectors is now automatically loaded.

Rsmlx 4.0.2 – (on GitHub and CRAN, March 4th, 2022).

Several bugs have been fixed, including:

• with bootmlx, datasets are generated but not run

• with buildmlx, ll=F produces an error

• with buildmlx, covariates used for stratification are not correctly managed

Rsmlx 4.0.1 – (on GitHub and CRAN, February 23rd, 2022).

• Rsmlx 4.0.1 is compatible with MonolixSuite 2021R1. It is not compatible with previous versions of Monolix.

• Rsmlx 4.0.1 includes two new functions for model building:

  • buildVar is designed to build the best variance model for the random effects by selecting which individual parameters vary and which ones are fixed,

  • buildAll builds the complete statistical model by iteratively calling functions buildmlx and buildVar.

• buildmlx has been improved. It now includes the use of statistical tests to check:

  • which covariate/parameter relationship or which correlation between random effects could have been missed,

  • which covariate/parameter relationship or which correlation could be removed (using the Wald test).

Rsmlx 3.0.3 – (on GitHub, May 18th, 2021)

• minor bug fixes

Rsmlx 3.0.0 – (on GitHub and CRAN, January 20th, 2021).

• Rsmlx 3.0.0 is compatible both with Monolix 2019 and Monolix 2020

Rsmlx 2.0.5 – (on GitHub, October 28th, 2020).

• bootmlx: parametric bootstap works properly

Rsmlx 2.0.4 – (on GitHub, June 12th, 2019).

• buildmlx: a bug introduced inadvertently in version 2.0.3 has been fixed

Rsmlx 2.0.3 – (on GitHub, June 7th, 2019).

• bug fixes:

  • pkpopini

  • buildmlx (bug when different names of observations in the model and in the data)

Rsmlx 2.0.2 – (on CRAN and GitHub, April 30th, 2019).

• Rsmlx 2.0 is on CRAN!

• This new version of Rsmlx runs with the MonolixSuite 2019R1

• No need to load the lixoftConnectors library

• See the install procedure.

Rsmlx 2.0.1 – (on GitHub, April 26th, 2019).

minor bug fixes

Rsmlx 2.0.0 – (on GitHub, April 19th, 2019).

Rsmlx 1.1.2 – (on GitHub, October 25th, 2018)

Rsmlx is now fully compatible with MlxConnectors of MonolixSuiteR2

Rsmlx 1.1.1 – (on GitHub, October 22nd, 2018)

• bootmlx: bug fixes

• getEstimatedIndividualParameters2: bug fix (eta’s were not correctly computed for normal distributions)

Rsmlx 1.1.0 – (on CRAN and GitHub, July 16th, 2018)

New functions:

• whichPKmodel

• readDatamlx

• pkpopini

• pkbuild

Rsmlx 1.0.2 – (on GitHub, July 6th, 2018)

• bootmlx: bug fix: it is now possible to have correlations between random effects in the model.

Rsmlx 1.0.1 – (on CRAN and GitHub, June 22th, 2018)

Rsmlx 1.0.0 – (on GitHub, May 28th, 2018)