Typical extensions of structural models

The following pages describe typical extensions of structural model:

• Joint model for continuous outcomes

• Mixture of structural models

• Using regressors

• Time varying parameters

  • Time-varying clearance

  • Auto-induction model

  • Enterohepatic circulation model

• Using a scale factor

• Delayed differential equations

• Additional model outputs

  • Outputs and tables

  • Computing additional model outputs such as Cmax or AUC

  • Calculating the half-life