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PKanalix
Monolix
Simulx
R API
Getting Started
Tutorials

Main

PKanalix
Monolix
Simulx
R API
Getting Started
Tutorials

Main

Introduction to Simulx

Why should I use Simulx?
The Simulx Workflows

New project

Import a Monolix project
Import a PKanalix project
New project from scratch

Definition

Model

Setting the model
Using or editing models from the libraries
Writing your own model

Model syntax: mlxtran language

Introduction: model structure for Simulx

[LONGITUDINAL]: Writing the structural and observation models Smlx

PK: Using PK macros

Introduction PK macros Smlx
depot macro
pkmodel macro
piecewise macros

EQUATION: Writing model equations

Ordinary differential equations (ODEs)
Delay differential equations (DDEs)

DEFINITION: Defining random variables

Continuous observation model
Time-to-event observation model
Count observation model
Categorical observation model

[INDIVIDUAL]: Defining parameter distributions
[COVARIATE]: describing covariates

Language reference

Reserved keywords
If/else statements
Mathematical functions
Probability distributions
Operators

Libraries of models

PK model library
PK/PD model library

TMDD model library

Introduction to TMDD concepts
TMDD library overview

Detailed TMDD models

Full model
Rapid binding (QE) and quasi steady-state (QSS) models
Constant Rtot TMDD model
Irreversible binding TMDD model
Wagner model
Irreversible binding and constant Rtot model
Michaelis-Menten model

Guidelines to choose a TMDD model

Library of PK models with double absorption
Library of parent–metabolite models
Tumor growth inhibition (TGI) library
Time-to-event model library
Count data model library

Typical models

Typical PK models

Mixed first-order and zero-order absorption, or parallel first-order
Saturation of the absorption rate
Absorption delays via sigmoid absorption, transit compartments or Weibull absorption

Models for non-continuous data

Time-to-event data models
Count data models
Categorical data models
Joint models for non-continuous outcomes

Typical extensions of structural models

Time-varying clearance
Auto-induction model
Enterohepatic circulation model
Computing additional model outputs such as Cmax or AUC
Calculating the half-life

Advanced models

Lifespan models
K-PD models
Friberg model for myelosupression
ADC model

External model editor

Occasions
Population parameters
Individual parameters
Covariates
Treatments
Outputs
Regressors

Exploration

Simulation

Building a simulation scenario
Outcomes and endpoints
Results
Plots

FAQ

Submission of Simulx runs to regulatory agencies

Advanced topics

Creating forest plots
Calculating exposure metrics
Plotting logistic regression curves
Simulating crossover trials

Breadcrumbs

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Simulx

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Advanced topics

Creating forest plots
Calculating exposure metrics
Plotting logistic regression curves
Simulating crossover trials

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