Overview of R packages

Applications of MonolixSuite can be controlled via the R package lixoftConnectors. This package offers functions that allow users to script all the actions that can be performed via the graphical user interface. The package is not available on CRAN, but can be found in the installation folder of MonolixSuite.

Rsmlx

The package Rsmlx requires lixoftConnectors and contains features that are not available in the graphical user interface, such as automated PK model building and calculation of profile likelihood.

RsSimulx

The package RsSimulx is a wrapper for lixoftConnectors Simulx functions. It can be used to re-run the scripts made using the deprecated mlxR package, and to perform simulations with an alternative syntax.

mlxDesignEval

The mlxDesignEval package evaluates the performance of NLME study designs by computing the Fisher Information Matrix directly from Monolix or Simulx projects. It provides expected RSEs, identifiability diagnostics, and design comparison tools. It requires MonolixSuite with Simulx and the lixoftConnectors package, as well as a specific license.

conc-QTc

The conc-QTc R scripts facilitate model-based concentration–QTc analysis by automating data formatting, Monolix model setup, and report generation. It supports both linear and nonlinear models and produces ready-to-use outputs through integration with MonolixSuite and lixoftConnectors.