The Monolix Workflow

A typical modeling workflow in 20 min

The modeling and estimation workflow

1. Set the data

2. Explore the data with interactive plots

3. Set the model

   1. Setting the structural model

   2. Setting the initial values

   3. Setting the statistical model

4. Run estimation tasks (population and individual parameters, conditional distribution, standard errors and likelihood)

In the following steps, compare models and track runs in Sycomore

5. Optimize the structural model with diagnostic plots, and the obtained standard errors and likelihood

6. Optimize the statistical model

   • manually with diagnostic plots and statistical tests

   • or with model building automated tools

7. Generate a report

and potentially

• Extend the study to a new dataset using a joint model (for example PD observation)

• Use the best model to perform simulations in Simulx