The Simulx Workflows

A typical Simulation Workflow with Simulx

https://youtu.be/uUwUWSC0WyY?feature=shared

Simulx Overview

Simulx has three sections that create an optimal environment to build and analyse simulations:

• Definition – create easily new exploration and simulation elements of different types.

• Exploration – explore different treatments and effects of model parameters on a typical individual.

• Simulation – simulate a clinical trial using a population of individuals in one or several groups with specific treatment or features and use flexible post-processing tools, clear results and interactive plots for analysis.

The exploration workflow

Goals:

• get a better understanding of how parameters impact your simulations

• explore the treatments and prepare your simulation design

Steps:

1. Import a Monolix project or Import a PKanalix project or create a New project from scratch

2. add new elements in the Definition tab: dosing regimens, parameters, covariates, outputs, etc.

3. explore effects of model parameters and treatments on a single individual

https://www.youtube.com/watch?v=CRK5D007MEc

The simulation workflow

Goals:

• simulate a population in a new situation, such as a clinical trial

• get quantitative answers to your questions

Steps:

1. Import a Monolix project or Import a PKanalix project or create a New project from scratch

2. add new elements in the definition tab: dosing regimens, parameters, covariates, outputs, etc.

3. combine defined elements into a desired simulation with one or several groups for comparison

4. (optional) create outcomes & endpoints to quantify the simulations outputs

5. get your answer with automatically generated results and plots