Reporting examples

NCA summary table split by a covariate

example: demo project_Theo_extravasc_SS.pkx

CODE

<lixoftPLH>
data:
    task: nca
    metrics: [Nobs, mean, CV, min, median, max]
    parameters: [Cmax, AUClast, CLss_F, Vz_F, HL_Lambda_z]
display:
    units: true
    inlineUnits: true
    metricsDirection: horizontal
    significantDigits: 4
    fitToContent: true
stratification:
    state: {split: [FORM]}
    splitDirection: [h]
</lixoftPLH>

BE table for absolute bioavailability

example: demo project_parallel_absBioavailability.pkx

CODE

<lixoftPLH>
data:
    task: be
    table: confidenceIntervals
    metrics: [Ratio, CILower, CIUpper]
    parameters: [AUCINF_obs, AUClast]
display:
    units: true
    inlineUnits: true
    significantDigits: 4
    fitToContent: true
renamings:
    bioequivalence: "Relative bioavailability (%) based on:"
    CILower: "Lower 90% CI"
    CIUpper: "Upper 90% CI"
</lixoftPLH>

Table of NCA settings

example: demo project_censoring.pkx

Data type	%data_type%
Dose type	%NCA_administrationType%
Weighting for λz slope calculation	%NCA_lambdaWeighting%
Point selection method for λz slope calculation	%NCA_lambdaRule%
AUC calculation method	%NCA_integralMethod%
BLQ before Tmax treated as	%NCA_blqMethodBeforeTmax%
BLQ after Tmax treated as	%NCA_blqMethodAfterTmax%

Individual NCA parameters for a group

example: demo DoseAndLOQ_byCategory.pkx

CODE

<lixoftPLH>
data:
    task: nca
    metrics: [ID]
    parameters: [AUCINF_D_obs, AUCINF_obs, AUClast, AUClast_D, Cmax, Cmax_D, Tmax]
display:
    units: true
    inlineUnits: true
    metricsDirection: vertical
    significantDigits: 2
    fitToContent: true
stratification:
    state: {split: [STUDY], filter: [[STUDY, [1]]]}
    splitDirection: [v]
</lixoftPLH>

NCA summary table with summary metrics filtered by group

example: demo DoseAndLOQ_byCategory.pkx

CODE

<lixoftPLH>
data:
    task: nca
    metrics: [Nobs, mean, SE, CV, min, median, max, geoMean, harmMean]
    parameters: [AUCINF_D_obs, AUCINF_obs, AUClast, AUClast_D, Cmax, Cmax_D, Tmax]
display:
    units: true
    inlineUnits: true
    metricsDirection: vertical
    significantDigits: 2
    fitToContent: true
stratification:
    state: {split: [STUDY], filter: [[STUDY, [1]]]}
    splitDirection: [v]
</lixoftPLH>

Individual covariate table

example: demo project_M2000_bolus_SD.pkx

CODE

<lixoftPLH>
data:
    task: nca
    metrics: [ID]
    excludedParameters: all
    covariates: all
    covariatesAfterParameters: true
display:
    units: true
    inlineUnits: true
    metricsDirection: vertical
    significantDigits: 4
    fitToContent: true
</lixoftPLH>

Included in LambdaZ table

example: demo project_censoring.pkx

CODE

<lixoftPLH>
data:
    task: nca
    table: pointsIncludedForLambdaZ
    metrics: [ID, time, concentration, BLQ, includedForLambdaZ]
display:
    significantDigits: 2
    fitToContent: true
</lixoftPLH>