Reporting examples

NCA summary table split by a covariate horizontally

example: demo project_Theo_extravasc_SS.pkx

CODE

<lixoftPLH>
data:
    task: nca
    metrics: [Nobs, mean, CV, min, median, max]
    parameters: [Cmax, AUClast, CLss_F, Vz_F, HL_Lambda_z]
display:
    units: true
    inlineUnits: true
    metricsDirection: horizontal
    significantDigits: 4
    fitToContent: true
stratification:
    state: {split: [FORM]}
    splitDirection: [h]
</lixoftPLH>

NCA summary table split by a covariate vertically

example: demo project_aPSCK9_SAD.pkx

In this example, the parameters are listed vertically, the summary metrics horizontally and the table is split by dose group vertically. The renamings are used to replace the summary metrics names.

CODE

<lixoftPLH>
data:
    task: nca
    metrics: [Nobs, mean, CV, min, median, max]
    parameters: [AUCINF_D_obs, AUClast_D, Cl_F_obs, Cmax_D, HL_Lambda_z, Tmax, Vz_F_obs]
display:
    units: true
    inlineUnits: true
    metricsDirection: horizontal
    significantDigits: 2
    fitToContent: true
stratification:
    state: {split: [DOSE_mg]}
    splitDirection: [v]
renamings:
    mean: MEAN
    Dose_mg: "Dose group"
    Metrics: "Parameter"
    min: MIN
    median: MEDIAN
    max: MAX
</lixoftPLH>

Individual NCA parameters and summary matrics in a single table

example: demo project_aPSCK9_SAD.pkx

By default when copying the tables from the GUI, individual NCA parameters and summary metrics are in two different tables but it is possible to merge them together by listing both ID and the summary metrics in the metrics argument. In this example, the table is also split by dose group and renamings are used.

CODE

<lixoftPLH>
data:
    task: nca
    metrics: [ID, mean, CV]
    parameters: [AUCINF_D_obs, Cl_F_obs, Cmax_D, HL_Lambda_z, Tmax]
display:
    units: true
    inlineUnits: false
    metricsDirection: vertical
    significantDigits: 2
    fitToContent: true
stratification:
    state: {split: [DOSE_mg]}
    splitDirection: [v]
renamings:
    mean: MEAN
    Dose_mg: "Dose group"
</lixoftPLH>

BE table for absolute bioavailability

example: demo project_parallel_absBioavailability.pkx

The default column name can be renamed using the renamings section to state “relative bioavailability” instead of “bioequivalence”.

CODE

<lixoftPLH>
data:
    task: be
    table: confidenceIntervals
    metrics: [Ratio, CILower, CIUpper]
    parameters: [AUCINF_obs, AUClast]
display:
    units: true
    inlineUnits: true
    significantDigits: 4
    fitToContent: true
renamings:
    bioequivalence: "Relative bioavailability (%) based on:"
    CILower: "Lower 90% CI"
    CIUpper: "Upper 90% CI"
</lixoftPLH>

Table of NCA settings

example: demo project_censoring.pkx

Data type	%data_type%
Dose type	%NCA_administrationType%
Weighting for λz slope calculation	%NCA_lambdaWeighting%
Point selection method for λz slope calculation	%NCA_lambdaRule%
AUC calculation method	%NCA_integralMethod%
BLQ before Tmax treated as	%NCA_blqMethodBeforeTmax%
BLQ after Tmax treated as	%NCA_blqMethodAfterTmax%

Individual NCA parameters for a group

example: demo DoseAndLOQ_byCategory.pkx

CODE

<lixoftPLH>
data:
    task: nca
    metrics: [ID]
    parameters: [AUCINF_D_obs, AUCINF_obs, AUClast, AUClast_D, Cmax, Cmax_D, Tmax]
display:
    units: true
    inlineUnits: true
    metricsDirection: vertical
    significantDigits: 2
    fitToContent: true
stratification:
    state: {split: [STUDY], filter: [[STUDY, [1]]]}
    splitDirection: [v]
</lixoftPLH>

NCA summary table with summary metrics filtered by group

example: demo DoseAndLOQ_byCategory.pkx

CODE

<lixoftPLH>
data:
    task: nca
    metrics: [Nobs, mean, SE, CV, min, median, max, geoMean, harmMean]
    parameters: [AUCINF_D_obs, AUCINF_obs, AUClast, AUClast_D, Cmax, Cmax_D, Tmax]
display:
    units: true
    inlineUnits: true
    metricsDirection: vertical
    significantDigits: 2
    fitToContent: true
stratification:
    state: {split: [STUDY], filter: [[STUDY, [1]]]}
    splitDirection: [v]
</lixoftPLH>

Individual covariate table

example: demo project_M2000_bolus_SD.pkx

By using excludedParameters: all, it is possible to hide all parameters and keep only covariates.

CODE

<lixoftPLH>
data:
    task: nca
    metrics: [ID]
    excludedParameters: all
    covariates: all
    covariatesAfterParameters: true
display:
    units: true
    inlineUnits: true
    metricsDirection: vertical
    significantDigits: 4
    fitToContent: true
</lixoftPLH>

Included in LambdaZ table

example: demo project_censoring.pkx

CODE

<lixoftPLH>
data:
    task: nca
    table: pointsIncludedForLambdaZ
    metrics: [ID, time, concentration, BLQ, includedForLambdaZ]
display:
    significantDigits: 2
    fitToContent: true
</lixoftPLH>

Individual NCA parameters for ref and test

example: demo project_Theo_extravasc_SD.pkx

The occasion column is shown by default but can be hidden with nbOccDisplayed: 0.

CODE

<lixoftPLH>
data:
    task: nca
    metrics: [ID]
    parameters: [AUCINF_obs, AUClast, Cmax]
    covariates: FORM
    covariatesAfterParameters: false
    nbOccDisplayed: 0
display:
    units: true
    inlineUnits: true
    metricsDirection: vertical
    significantDigits: 3
    fitToContent: true
</lixoftPLH>

Replacing missing values by “NC”

example: demo project_aPSCK9_SAD.pkx with modified point selection for lambdaZ for id 1

By default, NCA parameters which could not be calculated are displayed as empty cell. In order to replace the empty cell by a string, it is possible to display a NaN using displayNaNs: true and then using the renamings section to replace the NaN by another string, such as NC for instance.

CODE

<lixoftPLH>
data:
    task: nca
    metrics: [ID]
    parameters: [AUCINF_D_obs, AUClast_D, Cl_F_obs, Cmax_D]
    covariates: none
    covariatesAfterParameters: true
display:
    units: true
    inlineUnits: true
    metricsDirection: vertical
    significantDigits: 2
    fitToContent: true
    displayNaNs: true
</lixoftPLH>