List of reporting keywords

Keyword

Description

Possible values

%NCA_administrationType%

Administration type for NCA parameter calculation.

“intravenous” or “extravascular” if one adm id, otherwise “1: intravenous, 2: extravascular” with 1/2 corresponding to the administration id

%NCA_ObsIdUsed%

Observation id used for the NCA calculations.

string of the observation id, e.g “PK” or “1”

%data_type%

Type of data defined on the Data page.

“plasma” or “urine” if one observation id, otherwise “PK: plasma, PD: plasma” with PK/PD corresponding to the observation ids

%NCA_integralMethod%

Method for AUC and AUMC calculation and interpolation.

as in the associated dropdown menu (linear trapezoidal linear, linear log trapezoidal, linear up log down, linear trapezoidal linear/log)

%NCA_blqMethodBeforeTmax%

Method by which the BLQ data before Tmax should be replaced.

as in the associated dropdown menu (missing, zero, LOQ, LOQ/2)

%NCA_blqMethodAfterTmax%

Method by which the BLQ data after Tmax should be replaced.

as in the associated dropdown menu (missing, zero, LOQ, LOQ/2)

%NCA_ajdr2AcceptanceCriteria%

Value of the adjusted R2 acceptance criteria for the estimation of lambda_Z.

a number

%NCA_extrapAucAcceptanceCriteria%

Value of the AUC extrapolation acceptance criteria for the estimation of lambda_Z.

a number

%NCA_spanAcceptanceCriteria%

Span acceptance criteria for the estimation of lambda_Z.

a number

%NCA_lambdaRule%

General rule for the lambda_Z estimation. Includes information about the main rule, together with settings defined in the “rules” tab.

Examples:
“R2 with maximum 500 points, minimum time 20”
“Time interval between 10 and 50”
“Fixed number of points (3 points)”

%NCA_lambdaWeighting%

Weighting used for the lambda_Z estimation.

as in the associated dropdown menu (uniform, 1/Y, 1/Y²)

%CA_cost%

Cost function used for CA.

as in the associated dropdown menu ((Ypred – Yobs)², (Ypred – Yobs)² / Yobs, (Ypred – Yobs)² / Ypred, (Ypred – Yobs)² / Yobs², (Ypred – Yobs)² / Ypred², (Ypred – Yobs)² / |Ypred * Yobs|)

%CA_method%

Fit with individual parameters or with the same parameters for all individuals.

pooled fit, individual fit

%CA_blqMethod%

BLQ method for CA.

as in the associated dropdown menu (missing, zero, LOQ, LOQ/2)

%BE_level%

Level of the confidence interval for bioequivalence

a number

%BE_limits%

Limits in which the confidence interval must be to conclude the bioequivalence is true

Two numbers separated by a comma. Example:
0.8, 1.25

%BE_linearModelFactors%

Factors tested in the linear model for bioequivalence.

Data set column names. Example:
ID, PERIOD, FORM, SEQ

%BE_design%

Design of a bioequivalence study.

parallel, crossover

%BE_reference%

Categorical covariate modality selected as a reference

One of the modalities present in the data set. Example:
REF or IV

%TotalNbSubjects%

Total number of subjects in the data set (all observation ids together).

a number

%TotalNbSubjectsOcc%

Total number of subjects-occasions in the dataset (all observation ids together).

a number

%AvgNbDosesPerSubject%

Average number of doses per subject (any administration id, any occasion, all observation ids).

a number

%TotalNbObservations%

Total number of observations in the data set.

if one obs id, number, if several obs id, PK: xx, PD: xx

%AvgNbObservationsPerID%

Average number of observations per id (all occasions together).

if one obs id, number, if several obs id, PK: xx, PD: xx

%MinNbObservationsPerID%

Minimum number of observations per id (all occasions together).

if one obs id, number, if several obs id, PK: xx, PD: xx

%MaxNbObservationsPerID%

Maximum number of observations per id (all occasions together).

if one obs id, number, if several obs id, PK: xx, PD: xx

%PercentCensoredObservations%

Percentage of censored observations.

if one obs id, number, if several obs id, PK: xx, PD: xx

%StructModelCode%

Mlxtran code for the structural model.

whole structural model file content, as shown in the CA model tab

%reportGenerationDateTime(yyyy-MM-dd HH:mm:ss)%

Report generation date and time. Part of yyyy-MM-dd HH:mm:ss can be removed or reordered.

yyyy-MM-dd HH:mm:ss

%system%

Operating system on which report was generated.

Linux, macOS, Windows

%version%

Version of PKanalix with which report was generated.

2023R1

%project_fileName%

File name of the project (without path).

Example:
NCA_run.pkx

%project_filePath%

File path of the project.

Example:
C:/Users/user/lixoft/monolix/monolix2024R1/demos/1.creating_and_using_models/1.1.libraries_of_models/theophylline_project.mlxtran

%data_fileName%

File name of the data set (without path).

Example:
data.csv