********************************************************************************
*                         prj10_iov2_bootstrap.mlxtran                         *
*                         March 04, 2026 at 13:19:46                           *
*                         Monolix version : 2024R1                             *
********************************************************************************


ESTIMATION OF THE POPULATION PARAMETERS ________________________________________

Fixed Effects ----------------------------     se_sa    rse(%)   P2.5_sa  P97.5_sa
ka_pop          :                     1.43    0.0747      5.24      1.29      1.58
beta_ka_TREAT_B :                   0.0786    0.0307      39.1    0.0184     0.139
V_pop           :                     0.48    0.0105       2.2      0.46     0.501
beta_V_TREAT_B  :                   -0.191    0.0189      9.93    -0.228    -0.154
Cl_pop          :                   0.0414   0.00126      3.04     0.039     0.044
beta_Cl_TREAT_B :                   -0.215    0.0227      10.5     -0.26    -0.171

Standard Deviation of the Random Effects -
omega_ka        :                    0.287    0.0402        14     0.219     0.376
omega_V         :                    0.101    0.0197      19.6    0.0692     0.146
omega_Cl        :                    0.161    0.0218      13.5     0.124     0.209
gamma_ka        :                   0.0395    0.0285      72.3     0.013      0.12
gamma_V         :                   0.0491     0.018      36.7    0.0253     0.095
gamma_Cl        :                    0.071    0.0198      27.9    0.0423     0.119

Correlations -----------------------------
corr1_V_Cl      :                    0.473     0.186      39.4    0.0439     0.754
corr2_V_Cl      :                   -0.286     0.484       169    -0.869     0.628

Error Model Parameters -------------------
a               :                    0.119    0.0385      32.4    0.0658     0.215
b               :                    0.107   0.00901      8.45    0.0905     0.126

Elapsed time (seconds):       18
Exploratory phase iterations:      299 (Autostop)
Smoothing phase iterations:        109 (Autostop)

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ESTIMATION OF THE FISHER INFORMATION MATRIX ____________________________________


Estimation of the Fisher information matrix by Stochastic Approximation --------

Correlation Matrix :
         ka_pop         1
beta_ka_TREAT_B  -0.30776         1
          V_pop   0.19013  -0.20686         1
 beta_V_TREAT_B    -0.154   0.44789  -0.47203         1
         Cl_pop -0.038993  0.026853   0.18864  0.097547         1
beta_Cl_TREAT_B  0.032594 -0.032142   0.11452  -0.19278  -0.38862         1
       omega_ka  0.035178   0.05731 -0.026475  0.072208 0.0042526 0.0071919         1
        omega_V -0.029213  0.087419 -0.019639   0.10913  0.033953 -0.012599   0.22551         1
     corr1_V_Cl    0.0565  -0.13553  0.062527  -0.10293  0.018099 0.0019209  -0.10458 -0.083973         1
       omega_Cl -0.034087   0.11396 -0.019833  0.034906 0.0027184 -0.020581 0.0097203    0.1263   0.08841         1
       gamma_ka  0.039626  -0.22396 -0.036346 -0.047788 0.0040461 -0.097048 -0.038112 -0.014891  0.011401 -0.071958         1
        gamma_V-0.0021012  0.087838  0.061235 -0.051277 -0.052643  0.022253 -0.044997  -0.24274   0.250960.00038335  -0.16057         1
     corr2_V_Cl -0.050481   0.20974 -0.011671   0.10191-0.00084149   0.11347  0.096876   0.20285  -0.36269   0.10316  -0.38085  -0.21824         1
       gamma_Cl  0.066333  -0.13738  0.055564-0.0063192 -0.040841  0.097606  0.027469  -0.01665   0.17787  -0.24342  -0.12511 -0.042883 -0.048662         1
              a-0.0021474  0.079786  0.050485  -0.07583  -0.01509 -0.044572  -0.11036  -0.12259   0.12188  0.048965  0.073159   0.32412  -0.22403  -0.28061         1
              b 0.0070717 -0.092777  -0.02557  0.047909  0.025591  0.027595   0.06053  0.057837 -0.077705 -0.052477 -0.069653  -0.27947   0.16033   0.23227  -0.90314         1

                               min       max   max/min
Eigen values           :     0.089       2.5        28

Elapsed time (seconds):      2.6
Iterations:       50 (Autostop)

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 _______________________________________________________________________________


DATASET INFORMATION
Number of individuals: 40
Number of subjects-occasion: 80
Number of observations (Y): 800
Number of doses: 80

