********************************************************************************
*                         prj10_iov2_bootstrap.mlxtran                         *
*                         March 04, 2026 at 13:19:25                           *
*                         Monolix version : 2024R1                             *
********************************************************************************


ESTIMATION OF THE POPULATION PARAMETERS ________________________________________

Fixed Effects ----------------------------     se_sa    rse(%)   P2.5_sa  P97.5_sa
ka_pop          :                     1.49    0.0811      5.44      1.34      1.66
beta_ka_TREAT_B :                   0.0291    0.0438       150   -0.0567     0.115
V_pop           :                    0.475    0.0114      2.41     0.453     0.498
beta_V_TREAT_B  :                   -0.185    0.0223      12.1    -0.229    -0.141
Cl_pop          :                    0.041   0.00118      2.88    0.0387    0.0434
beta_Cl_TREAT_B :                   -0.205    0.0299      14.6    -0.263    -0.146

Standard Deviation of the Random Effects -
omega_ka        :                    0.287    0.0398      13.9     0.219     0.375
omega_V         :                    0.115    0.0192      16.7    0.0835     0.159
omega_Cl        :                    0.122    0.0233      19.1     0.085     0.176
gamma_ka        :                   0.0747    0.0597      79.9    0.0228     0.245
gamma_V         :                   0.0615    0.0159      25.8     0.038    0.0998
gamma_Cl        :                    0.114    0.0181      15.9     0.084     0.155

Correlations -----------------------------
corr1_V_Cl      :                    0.321     0.238      74.1    -0.185     0.692
corr2_V_Cl      :                  -0.0589     0.276       469    -0.539      0.45

Error Model Parameters -------------------
a               :                    0.122    0.0371      30.5    0.0694     0.213
b               :                    0.102   0.00871      8.58    0.0859      0.12

Elapsed time (seconds):       13
Exploratory phase iterations:      262 (Autostop)
Smoothing phase iterations:        123 (Autostop)

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ESTIMATION OF THE FISHER INFORMATION MATRIX ____________________________________


Estimation of the Fisher information matrix by Stochastic Approximation --------

Correlation Matrix :
         ka_pop         1
beta_ka_TREAT_B  -0.40165         1
          V_pop   0.18208  -0.23612         1
 beta_V_TREAT_B   -0.2168   0.53084  -0.46491         1
         Cl_pop -0.030325  0.035068   0.11292  0.050115         1
beta_Cl_TREAT_B  0.013162 -0.026618  0.038259 -0.073589  -0.52272         1
       omega_ka  0.073459 -0.092007  0.014377 -0.059223-0.0057122-0.00035358         1
        omega_V  0.010119 -0.030658  0.018686 -0.028676-0.0016841  0.011788   0.15768         1
     corr1_V_Cl   0.02972 -0.058124 0.0052866 -0.025601  0.038892 -0.030708-0.0085278  0.016598         1
       omega_Cl -0.029412  0.074105 -0.024813   0.05423 -0.027668  0.025781 -0.014973  0.037749  -0.04112         1
       gamma_ka  -0.16116   0.42641  -0.10731   0.24729  0.013284  0.075367  -0.13988  0.052512  -0.12175  0.087702         1
        gamma_V  0.035701  -0.13447-0.0040184 -0.035238 -0.010389 -0.035407  0.043686  -0.18642   0.14796 -0.039841    -0.387         1
     corr2_V_Cl -0.055023   0.13139 -0.015407   0.03579 -0.012036  0.061923 -0.029816  0.024391  -0.31556  0.082863   0.21078  -0.14913         1
       gamma_Cl  0.022973 -0.051552  0.016964 -0.036221  0.017644 -0.053832  0.002494 -0.014533   0.16662  -0.37558 -0.068111  0.027675  -0.15795         1
              a-0.0058257  0.019618-0.0022818-0.0022435  0.010531 -0.021558 -0.048228   -0.0457   0.14661  -0.05938 -0.050194   0.15077 -0.007863 -0.011974         1
              b  0.024945 -0.056499  0.030141 -0.022351-0.0056723  0.015458   0.02329  0.014273  -0.11957  0.043732 -0.037669  -0.13544 -0.030869  0.001099  -0.89838         1

                               min       max   max/min
Eigen values           :     0.095       2.4        26

Elapsed time (seconds):      1.9
Iterations:       60 (Autostop)

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 _______________________________________________________________________________


DATASET INFORMATION
Number of individuals: 40
Number of subjects-occasion: 80
Number of observations (Y): 800
Number of doses: 80

