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*                         prj10_iov2_bootstrap.mlxtran                         *
*                         March 04, 2026 at 13:19:10                           *
*                         Monolix version : 2024R1                             *
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ESTIMATION OF THE POPULATION PARAMETERS ________________________________________

Fixed Effects ----------------------------     se_sa    rse(%)   P2.5_sa  P97.5_sa
ka_pop          :                      1.4    0.0645      4.62      1.28      1.53
beta_ka_TREAT_B :                    0.141    0.0445      31.5     0.054     0.228
V_pop           :                     0.47    0.0111      2.37     0.449     0.492
beta_V_TREAT_B  :                    -0.18    0.0255      14.1     -0.23     -0.13
Cl_pop          :                     0.04   0.00123      3.07    0.0377    0.0425
beta_Cl_TREAT_B :                   -0.194    0.0297      15.3    -0.252    -0.136

Standard Deviation of the Random Effects -
omega_ka        :                    0.213    0.0357      16.8     0.155     0.294
omega_V         :                   0.0982    0.0246        25    0.0614     0.157
omega_Cl        :                    0.142    0.0246      17.3     0.102     0.198
gamma_ka        :                    0.114    0.0331        29    0.0666     0.195
gamma_V         :                   0.0835     0.027      32.4    0.0462     0.151
gamma_Cl        :                    0.111    0.0192      17.3    0.0798     0.155

Correlations -----------------------------
corr1_V_Cl      :                   -0.389     0.289      74.2    -0.792     0.251
corr2_V_Cl      :                     0.44     0.269        61    -0.179      0.81

Error Model Parameters -------------------
a               :                    0.108    0.0379      35.1    0.0573     0.204
b               :                    0.106    0.0089      8.41    0.0899     0.125

Elapsed time (seconds):       12
Exploratory phase iterations:      275 (Autostop)
Smoothing phase iterations:        106 (Autostop)

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ESTIMATION OF THE FISHER INFORMATION MATRIX ____________________________________


Estimation of the Fisher information matrix by Stochastic Approximation --------

Correlation Matrix :
         ka_pop         1
beta_ka_TREAT_B  -0.48733         1
          V_pop   0.18896  -0.19635         1
 beta_V_TREAT_B  -0.17223   0.36408  -0.53521         1
         Cl_pop -0.033238   0.03501 -0.077854  -0.10011         1
beta_Cl_TREAT_B  0.037669 -0.079507  -0.10554   0.19848  -0.48517         1
       omega_ka  0.031423  -0.01006 -0.017574  0.023342-0.0023218-0.0023748         1
        omega_V -0.011067  0.011436  0.014938 -0.038154-0.0038143 -0.012612    0.1527         1
     corr1_V_Cl-0.00257450.00096499-0.0019421-0.0044291  0.022799 -0.034069  0.065453   0.36061         1
       omega_Cl  0.018302 -0.020726 0.0033939 0.0049323 -0.025301-0.0033102  0.025819   0.14701    0.1634         1
       gamma_ka -0.048215   0.12898  0.056726 -0.066086-0.00019363  0.011721  -0.24296 -0.058979  -0.14251 -0.061943         1
        gamma_V  0.019455 0.0060095 -0.038137   0.12461-0.0041996 0.0089534  -0.03031  -0.51284  -0.49874   -0.1421  0.086173         1
     corr2_V_Cl -0.010031 0.0039933  0.063208  -0.11563 -0.040422    0.1079  -0.07143  -0.19477  -0.46317  -0.23253    0.3159   0.19238         1
       gamma_Cl 0.0056479-0.0038215  0.026075 -0.033862 0.0040306-0.0057605 -0.029817  -0.18118  -0.44475  -0.39136   0.10115   0.22119   0.41596         1
              a -0.033891  0.039852 -0.032173  0.024192  0.026969 -0.017198 -0.086271 -0.059266  0.067814 -0.011899  0.015888  0.075908  0.047922  -0.17361         1
              b  0.030912 -0.041476  0.037795 -0.019587  -0.01945  0.020628  0.054945   0.01824 -0.074987 0.0061432 -0.059575 -0.063759 -0.045136   0.14191  -0.90106         1

                               min       max   max/min
Eigen values           :     0.094       2.7        28

Elapsed time (seconds):      1.7
Iterations:       50 (Autostop)

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DATASET INFORMATION
Number of individuals: 40
Number of subjects-occasion: 80
Number of observations (Y): 800
Number of doses: 80

