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*                         prj10_iov2_bootstrap.mlxtran                         *
*                         March 04, 2026 at 13:18:57                           *
*                         Monolix version : 2024R1                             *
********************************************************************************


ESTIMATION OF THE POPULATION PARAMETERS ________________________________________

Fixed Effects ----------------------------     se_sa    rse(%)   P2.5_sa  P97.5_sa
ka_pop          :                     1.48    0.0866      5.84      1.32      1.66
beta_ka_TREAT_B :                  0.00633     0.034       537   -0.0603     0.073
V_pop           :                    0.477    0.0129      2.71     0.452     0.503
beta_V_TREAT_B  :                   -0.216    0.0237      10.9    -0.263     -0.17
Cl_pop          :                   0.0414   0.00128       3.1     0.039     0.044
beta_Cl_TREAT_B :                    -0.24    0.0295      12.3    -0.298    -0.182

Standard Deviation of the Random Effects -
omega_ka        :                    0.332    0.0439      13.2     0.257     0.429
omega_V         :                    0.132    0.0371        28    0.0786     0.223
omega_Cl        :                    0.143     0.032      22.3     0.094     0.219
gamma_ka        :                   0.0474    0.0373      78.8    0.0146     0.154
gamma_V         :                   0.0804    0.0319      39.6    0.0397     0.163
gamma_Cl        :                     0.11    0.0375        34    0.0596     0.205

Correlations -----------------------------
corr1_V_Cl      :                    0.752     0.332      44.2    -0.478     0.986
corr2_V_Cl      :                   -0.345     0.473       137    -0.888       0.6

Error Model Parameters -------------------
a               :                     0.16    0.0353      22.1     0.105     0.243
b               :                   0.0832   0.00783      9.41    0.0693       0.1

Elapsed time (seconds):      9.4
Exploratory phase iterations:      249 (Autostop)
Smoothing phase iterations:        101 (Autostop)

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ESTIMATION OF THE FISHER INFORMATION MATRIX ____________________________________


Estimation of the Fisher information matrix by Stochastic Approximation --------

Correlation Matrix :
         ka_pop         1
beta_ka_TREAT_B  -0.29666         1
          V_pop   0.12279  -0.19155         1
 beta_V_TREAT_B  -0.12748   0.41336  -0.45153         1
         Cl_pop -0.033988  0.056507    0.2895   0.15428         1
beta_Cl_TREAT_B   0.03605  -0.12971   0.14233  -0.31967  -0.48556         1
       omega_ka   0.04296  0.015653 0.0030273  0.010989 0.0067919-0.0048294         1
        omega_V  0.010811  0.029947  0.033377 0.0062339-0.0041398  0.022111   0.16056         1
     corr1_V_Cl  -0.02697  0.034398 -0.036761  0.047559   0.04442 -0.067231 -0.027813  -0.55435         1
       omega_Cl  0.024674 -0.047363  0.031289 -0.052282 -0.034215  0.068812 0.0095128   0.46398  -0.63435         1
       gamma_ka -0.033793    0.2732 -0.006209  0.094997-0.0011914 -0.060444 -0.023954   0.10245  -0.13428  0.044426         1
        gamma_V -0.021193 -0.016908 -0.025373  0.028385  0.029268 -0.046993-0.00069647  -0.45286   0.77343  -0.51639  -0.29309         1
     corr2_V_Cl  0.049301 -0.090523  0.056838 -0.091381 -0.029722  0.068858  0.021872   0.45384  -0.84819   0.65661  0.094489  -0.73063         1
       gamma_Cl -0.020946    0.0322 -0.025334   0.05237  0.031585 -0.082478 -0.019568  -0.41741   0.80942  -0.76471 -0.052668   0.62248  -0.79818         1
              a -0.024482  0.074802 -0.031494  0.037522  0.062043  -0.06731  0.053474  -0.15266   0.35228  -0.27702  -0.10365   0.31808  -0.30299   0.26081         1
              b   0.02324 -0.084185  0.034653 -0.036491 -0.052202  0.065549 -0.070653   0.10144  -0.28671   0.22558  0.056867  -0.25971   0.23676  -0.21746  -0.90227         1

                               min       max   max/min
Eigen values           :     0.091       4.6        50

Elapsed time (seconds):      2.1
Iterations:       78 (Autostop)

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 _______________________________________________________________________________


DATASET INFORMATION
Number of individuals: 40
Number of subjects-occasion: 80
Number of observations (Y): 800
Number of doses: 80

