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*                         prj10_iov2_bootstrap.mlxtran                         *
*                         March 04, 2026 at 13:18:45                           *
*                         Monolix version : 2024R1                             *
********************************************************************************


ESTIMATION OF THE POPULATION PARAMETERS ________________________________________

Fixed Effects ----------------------------     se_sa    rse(%)   P2.5_sa  P97.5_sa
ka_pop          :                     1.42    0.0706      4.99      1.28      1.56
beta_ka_TREAT_B :                   0.0336    0.0493       147    -0.063      0.13
V_pop           :                    0.467    0.0118      2.53     0.444      0.49
beta_V_TREAT_B  :                   -0.192    0.0254      13.2    -0.242    -0.142
Cl_pop          :                   0.0383    0.0013      3.38    0.0359    0.0409
beta_Cl_TREAT_B :                   -0.164    0.0323      19.7    -0.227    -0.101

Standard Deviation of the Random Effects -
omega_ka        :                     0.24    0.0344      14.3     0.182     0.316
omega_V         :                    0.112    0.0232      20.7    0.0758     0.166
omega_Cl        :                    0.159    0.0283      17.7     0.114     0.224
gamma_ka        :                   0.0571    0.0911       160    0.0102     0.321
gamma_V         :                   0.0769    0.0265      34.5    0.0411     0.144
gamma_Cl        :                    0.121    0.0246      20.3    0.0824     0.178

Correlations -----------------------------
corr1_V_Cl      :                    0.403     0.275      68.2    -0.213      0.79
corr2_V_Cl      :                   -0.284     0.389       137    -0.808     0.491

Error Model Parameters -------------------
a               :                    0.105    0.0433      41.1    0.0509     0.218
b               :                    0.106   0.00912      8.61    0.0896     0.125

Elapsed time (seconds):        9
Exploratory phase iterations:      248 (Autostop)
Smoothing phase iterations:        120 (Autostop)

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ESTIMATION OF THE FISHER INFORMATION MATRIX ____________________________________


Estimation of the Fisher information matrix by Stochastic Approximation --------

Correlation Matrix :
         ka_pop         1
beta_ka_TREAT_B  -0.52557         1
          V_pop   0.24683  -0.31417         1
 beta_V_TREAT_B  -0.25682   0.51547   -0.5093         1
         Cl_pop  -0.01839 0.0067358    0.1129   0.09351         1
beta_Cl_TREAT_B -0.032292  0.064016  0.069642  -0.18011  -0.46923         1
       omega_ka  0.020173-0.0030106 0.0030782  0.043359-4.7837e-05 -0.047146         1
        omega_V -0.061351  0.079461 -0.053991 -0.015473 -0.015804  0.064291  0.054471         1
     corr1_V_Cl   0.13265  -0.20379  0.093741 -0.022194  0.019344  -0.11612   0.07571  -0.26244         1
       omega_Cl -0.099043   0.16388 -0.064346  0.031185 -0.028335  0.085742  -0.05854   0.20997  -0.26252         1
       gamma_ka  -0.21751   0.32496  -0.13928 0.0018954 -0.027418   0.21789  -0.21343   0.29106  -0.51016   0.35884         1
        gamma_V   0.12568  -0.17691  0.077248 0.0076617   0.01505  -0.12583   0.10601  -0.44738   0.53163  -0.24542  -0.53464         1
     corr2_V_Cl  -0.17965   0.28111  -0.12042  0.028076-0.0078962   0.15786  -0.12114    0.2819  -0.62989    0.3773   0.66028  -0.48219         1
       gamma_Cl   0.16269  -0.23918   0.10746 -0.022786  0.015014  -0.15407   0.10526  -0.27065   0.52794  -0.47171  -0.59311   0.41803  -0.60932         1
              a  0.097667  -0.13106  0.081552 -0.017061  0.010983 -0.069791  0.091536  -0.17144   0.35545  -0.19503  -0.40583   0.35279  -0.35794   0.23403         1
              b-0.0058394-0.0093449 -0.013963-0.0020061 0.0031362  0.002025 -0.052518  0.065218  -0.18264  0.069293  0.087135  -0.19219   0.12663 -0.054157   -0.8638         1

                               min       max   max/min
Eigen values           :     0.074       4.3        58

Elapsed time (seconds):      1.5
Iterations:       52 (Autostop)

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DATASET INFORMATION
Number of individuals: 40
Number of subjects-occasion: 80
Number of observations (Y): 800
Number of doses: 80

