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*                         prj10_iov2_bootstrap.mlxtran                         *
*                         March 04, 2026 at 13:18:35                           *
*                         Monolix version : 2024R1                             *
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ESTIMATION OF THE POPULATION PARAMETERS ________________________________________

Fixed Effects ----------------------------     se_sa    rse(%)   P2.5_sa  P97.5_sa
ka_pop          :                     1.42    0.0652      4.58       1.3      1.56
beta_ka_TREAT_B :                   0.0615    0.0425      69.1   -0.0218     0.145
V_pop           :                    0.474    0.0119      2.51     0.451     0.498
beta_V_TREAT_B  :                   -0.186     0.028      15.1    -0.241    -0.131
Cl_pop          :                   0.0406   0.00124      3.05    0.0383    0.0431
beta_Cl_TREAT_B :                   -0.244    0.0334      13.7    -0.309    -0.178

Standard Deviation of the Random Effects -
omega_ka        :                    0.217    0.0346        16      0.16     0.295
omega_V         :                   0.0985    0.0963      97.8    0.0257     0.377
omega_Cl        :                    0.121     0.135       112    0.0285     0.514
gamma_ka        :                   0.0861    0.0376      43.7    0.0401     0.185
gamma_V         :                   0.0947    0.0999       105    0.0233     0.384
gamma_Cl        :                    0.129     0.142       110    0.0308     0.543

Correlations -----------------------------
corr1_V_Cl      :                    0.649      2.35       363        -1         1
corr2_V_Cl      :                   -0.422       1.2       285    -0.997     0.984

Error Model Parameters -------------------
a               :                    0.155    0.0695      44.8    0.0711     0.338
b               :                   0.0926    0.0141      15.2    0.0691     0.124

Elapsed time (seconds):       10
Exploratory phase iterations:      289 (Autostop)
Smoothing phase iterations:         95 (Autostop)

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ESTIMATION OF THE FISHER INFORMATION MATRIX ____________________________________


Estimation of the Fisher information matrix by Stochastic Approximation --------

Correlation Matrix :
         ka_pop         1
beta_ka_TREAT_B  -0.46339         1
          V_pop     0.212  -0.22378         1
 beta_V_TREAT_B  -0.18815   0.43329  -0.54721         1
         Cl_pop -0.045903  0.029885  0.035574   0.17566         1
beta_Cl_TREAT_B  0.039471 -0.097893   0.19584  -0.35724  -0.54795         1
       omega_ka  0.027333 -0.019741 0.0086705 -0.023987  0.024512 -0.024741         1
        omega_V 0.0077961  -0.22505 0.0072831  -0.18576  0.056142  0.022234   0.25782         1
     corr1_V_Cl-0.0051637   0.24019 0.0069153   0.19796 -0.057317 -0.027884  -0.21274  -0.94947         1
       omega_Cl 0.0055999  -0.23597-0.0066359  -0.19621  0.058875  0.025049   0.20931   0.92683  -0.97903         1
       gamma_ka  0.035818  -0.20606 -0.015461  -0.12019  0.003833  0.052748 -0.082856   0.44551  -0.47673   0.45919         1
        gamma_V-0.0099493   0.25398  0.011015   0.20214 -0.057535 -0.035657  -0.16815  -0.91526   0.97155  -0.94782  -0.50248         1
     corr2_V_Cl  0.010503  -0.24111 -0.002294  -0.20228  0.058359  0.030029   0.20582   0.92932  -0.98603   0.97357   0.47207  -0.96169         1
       gamma_Cl -0.007484   0.23935 0.0049368   0.19875 -0.061895 -0.024747  -0.21144     -0.93    0.9865  -0.98696  -0.46034   0.95495  -0.98208         1
              a  0.026028   0.21098   0.04436   0.15934 -0.059756 -0.032843  -0.18404  -0.78661   0.83644  -0.82517  -0.40029   0.82167  -0.82076    0.8201         1
              b -0.028546  -0.19815 -0.038132  -0.15058  0.061031  0.031393   0.15928   0.73091  -0.78211   0.77298   0.34775  -0.76999   0.76498   -0.7689  -0.96411         1

                               min       max   max/min
Eigen values           :    0.0078       7.6   9.8e+02

Elapsed time (seconds):      2.8
Iterations:       72 (Autostop)

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DATASET INFORMATION
Number of individuals: 40
Number of subjects-occasion: 80
Number of observations (Y): 800
Number of doses: 80

