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*                         prj10_iov2_bootstrap.mlxtran                         *
*                         March 04, 2026 at 13:18:21                           *
*                         Monolix version : 2024R1                             *
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ESTIMATION OF THE POPULATION PARAMETERS ________________________________________

Fixed Effects ----------------------------     se_sa    rse(%)   P2.5_sa  P97.5_sa
ka_pop          :                     1.47    0.0815      5.53      1.32      1.64
beta_ka_TREAT_B :                   0.0679    0.0446      65.7   -0.0195     0.155
V_pop           :                    0.481    0.0123      2.56     0.458     0.506
beta_V_TREAT_B  :                   -0.202    0.0236      11.7    -0.248    -0.156
Cl_pop          :                   0.0406   0.00116      2.85    0.0384     0.043
beta_Cl_TREAT_B :                   -0.207    0.0313      15.1    -0.268    -0.146

Standard Deviation of the Random Effects -
omega_ka        :                    0.285    0.0396      13.9     0.217     0.372
omega_V         :                    0.116    0.0352      30.3    0.0666     0.203
omega_Cl        :                     0.11    0.0276      25.2    0.0683     0.176
gamma_ka        :                    0.077    0.0356      46.2    0.0347     0.171
gamma_V         :                   0.0737    0.0217      29.4    0.0428     0.127
gamma_Cl        :                    0.117    0.0287      24.4    0.0741     0.186

Correlations -----------------------------
corr1_V_Cl      :                    0.695     0.353      50.8    -0.445     0.975
corr2_V_Cl      :                   -0.448     0.276      61.5    -0.821     0.192

Error Model Parameters -------------------
a               :                    0.172    0.0393      22.9     0.111     0.264
b               :                   0.0916   0.00855      9.33    0.0764      0.11

Elapsed time (seconds):      8.4
Exploratory phase iterations:      263 (Autostop)
Smoothing phase iterations:        114 (Autostop)

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ESTIMATION OF THE FISHER INFORMATION MATRIX ____________________________________


Estimation of the Fisher information matrix by Stochastic Approximation --------

Correlation Matrix :
         ka_pop         1
beta_ka_TREAT_B  -0.42228         1
          V_pop   0.19391  -0.22564         1
 beta_V_TREAT_B   -0.2053   0.46803  -0.48194         1
         Cl_pop -0.054971  0.065943   0.10166   0.21083         1
beta_Cl_TREAT_B  0.054774  -0.11233   0.18583   -0.3746  -0.56556         1
       omega_ka  0.057008  0.027409  0.031336 0.0029239   0.01356-0.0090636         1
        omega_V 0.0042603-0.0050841   0.11529 -0.010059 0.0058308-0.0080257   0.24207         1
     corr1_V_Cl0.00058904  0.031716 -0.040071-0.0022232 0.0026517  0.042037 -0.068674   -0.3552         1
       omega_Cl  0.022428 -0.028564  0.001716 0.0013385   0.03011 -0.047533-0.0087539  0.058579  -0.41539         1
       gamma_ka  0.086138  -0.29191 0.0032607  -0.13578 -0.026837  0.023109  -0.14461 -0.084556 -0.054536  0.041059         1
        gamma_V-0.0020337  0.086748  0.059181  0.031257 -0.015621-0.00078919   0.11014  0.076012   0.32293  -0.15831  -0.25885         1
     corr2_V_Cl  0.027164 -0.026225  0.0219670.00046445  0.038258  -0.02426  0.016803  0.024359    -0.547   0.42986  0.023181   -0.2525         1
       gamma_Cl -0.038598  0.057855 -0.015595  0.012628 -0.057407  0.061348 0.0030292 -0.019359   0.57462  -0.71752  -0.04173   0.23037  -0.58231         1
              a -0.024247   0.15668  0.013085  0.050016-0.0074407  0.002676 -0.012137  -0.10815   0.20559 -0.048077  -0.23067   0.18054 -0.066784  0.012127         1
              b  0.015615   -0.1226-0.0026728 -0.038132  0.011854-0.0041567-0.0041675  0.089774  -0.17579  0.042098   0.13883   -0.1562  0.026153 -0.023824  -0.89871         1

                               min       max   max/min
Eigen values           :     0.092       2.9        32

Elapsed time (seconds):      1.1
Iterations:       50 (Autostop)

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 _______________________________________________________________________________


DATASET INFORMATION
Number of individuals: 40
Number of subjects-occasion: 80
Number of observations (Y): 800
Number of doses: 80

