********************************************************************************
*                         prj10_iov2_bootstrap.mlxtran                         *
*                         March 04, 2026 at 13:17:43                           *
*                         Monolix version : 2024R1                             *
********************************************************************************


ESTIMATION OF THE POPULATION PARAMETERS ________________________________________

Fixed Effects ----------------------------     se_sa    rse(%)   P2.5_sa  P97.5_sa
ka_pop          :                     1.56      0.07      4.48      1.43      1.71
beta_ka_TREAT_B :                   0.0621    0.0387      62.3   -0.0137     0.138
V_pop           :                    0.479   0.00974      2.03     0.461     0.499
beta_V_TREAT_B  :                   -0.193    0.0195      10.1    -0.231    -0.155
Cl_pop          :                   0.0425   0.00106      2.49    0.0404    0.0446
beta_Cl_TREAT_B :                   -0.233    0.0309      13.3    -0.294    -0.172

Standard Deviation of the Random Effects -
omega_ka        :                    0.225    0.0332      14.8     0.169     0.299
omega_V         :                    0.093    0.0158        17    0.0671     0.129
omega_Cl        :                   0.0748    0.0271      36.2    0.0389     0.144
gamma_ka        :                   0.0706     0.024        34     0.038     0.131
gamma_V         :                   0.0485    0.0118      24.4    0.0306    0.0767
gamma_Cl        :                     0.12    0.0185      15.5    0.0889     0.161

Correlations -----------------------------
corr1_V_Cl      :                  -0.0186      0.34  1.82e+03    -0.595      0.57
corr2_V_Cl      :                    0.298     0.278      93.2    -0.282     0.718

Error Model Parameters -------------------
a               :                    0.105    0.0352      33.5    0.0571     0.194
b               :                    0.108   0.00837      7.76    0.0927     0.125

Elapsed time (seconds):        7
Exploratory phase iterations:      247 (Autostop)
Smoothing phase iterations:        137 (Autostop)

 _______________________________________________________________________________




ESTIMATION OF THE FISHER INFORMATION MATRIX ____________________________________


Estimation of the Fisher information matrix by Stochastic Approximation --------

Correlation Matrix :
         ka_pop         1
beta_ka_TREAT_B  -0.40514         1
          V_pop   0.20156  -0.20493         1
 beta_V_TREAT_B   -0.1956   0.48764  -0.47354         1
         Cl_pop -0.031153  0.022286  0.048892 -0.069929         1
beta_Cl_TREAT_B  0.030823 -0.079562 -0.037397  0.070417  -0.62066         1
       omega_ka  0.041296   0.01292-0.0010924   0.02128-0.0052567 0.0012798         1
        omega_V -0.017273   0.05542 -0.047459  0.072722-0.0094778 0.0053792   0.18738         1
     corr1_V_Cl  0.037116 -0.038896 0.0090187 -0.010074  0.021075-0.0090874  0.040105  0.035709         1
       omega_Cl -0.010688 0.0063164 0.0066006 -0.013689 -0.018905-0.0075893 -0.030983 -0.018137  0.035806         1
       gamma_ka  0.086359   -0.2179   0.10926  -0.19066 -0.025705  0.057807  -0.10119 -0.084359  0.040847    0.0184         1
        gamma_V  -0.03657  0.076674 -0.016062  0.049306-0.0058679  -0.03012  0.010479  -0.17225  -0.06828  0.068714 -0.037203         1
     corr2_V_Cl  0.030541 -0.061123   0.06251 -0.072409 0.0069186  0.010453 -0.0156140.00024627  -0.31573  0.029597   0.14464 -0.018392         1
       gamma_Cl  0.020593  -0.02697 0.0011665-0.0045466 -0.023623  0.032258  0.035476  0.038564 -0.059364  -0.55437 -0.039832 -0.070045 -0.038187         1
              a  0.027631  0.019542  0.043984  0.029402   0.01349 -0.049416   -0.0477 -0.081962   0.17887 -0.025542    0.1171  0.014897   0.08619  -0.15819         1
              b -0.021519 -0.023614 -0.023303 -0.030496 0.0024439  0.0426870.00058288  0.039529   -0.1636  0.020372  -0.14314 -0.079983 -0.077046   0.12893  -0.88624         1

                               min       max   max/min
Eigen values           :      0.11       2.2        20

Elapsed time (seconds):     0.92
Iterations:       50 (Autostop)

 -------------------------------------------------------------------------------

 _______________________________________________________________________________


DATASET INFORMATION
Number of individuals: 40
Number of subjects-occasion: 80
Number of observations (Y): 800
Number of doses: 80

