********************************************************************************
*                           prj08_iov2.mlxtran                                 *
*                            at                                                *
*                           Monolix version : 2024R1                           *
********************************************************************************


ESTIMATION OF THE POPULATION PARAMETERS ________________________________________

Fixed Effects ----------------------------     se_sa    rse(%)   P2.5_sa  P97.5_sa
ka_pop          :                     1.48    0.0805      5.45      1.33      1.64
beta_ka_TREAT_B :                   0.0714    0.0435      60.9   -0.0138     0.157
V_pop           :                    0.474    0.0132      2.79     0.449     0.501
beta_V_TREAT_B  :                    -0.18    0.0288        16    -0.236    -0.123
Cl_pop          :                   0.0405   0.00129      3.18     0.038    0.0431
beta_Cl_TREAT_B :                   -0.205    0.0353      17.2    -0.275    -0.136

Standard Deviation of the Random Effects -
omega_ka        :                    0.273    0.0384      14.1     0.208     0.358
omega_V         :                    0.116    0.0521        45    0.0529     0.253
omega_Cl        :                    0.117    0.0966      82.8    0.0347     0.393
gamma_ka        :                   0.0488    0.0272      55.7    0.0194     0.123
gamma_V         :                   0.0885    0.0716      80.9    0.0268     0.293
gamma_Cl        :                    0.129     0.106      82.5    0.0384     0.433

Correlations -----------------------------
corr1_V_Cl      :                     0.65      1.37       210    -0.999         1
corr2_V_Cl      :                   -0.494     0.801       162    -0.989     0.912

Error Model Parameters -------------------
a               :                    0.142     0.043      30.4     0.081     0.248
b               :                   0.0992   0.00946      9.54    0.0823     0.119

Elapsed time (seconds):      5.3
Exploratory phase iterations:      244 (Autostop)
Smoothing phase iterations:        112 (Autostop)

 _______________________________________________________________________________



ESTIMATION OF THE INDIVIDUAL PARAMETERS ________________________________________


Estimation of the individual parameters by Conditional Distribution ------------
               min            Q1        median            Q3           max  shrinkage(%)
ka :          0.89          1.33          1.53          1.94          2.69          4.82
V  :         0.319         0.395         0.447         0.473         0.589          27.6
Cl :        0.0222         0.032        0.0358        0.0428        0.0583         -3.12

Elapsed time (seconds):      1.1
Iterations:       70 (Autostop)

 -------------------------------------------------------------------------------


Estimation of the individual parameters by Conditional Mode --------------------
               min            Q1        median            Q3           max  shrinkage(%)
ka :         0.873           1.3          1.47          1.89          2.55          6.11
V  :         0.316         0.389         0.442         0.473         0.578          27.6
Cl :        0.0224        0.0322        0.0361        0.0434        0.0588         -3.03

Elapsed time (seconds):    0.039

 -------------------------------------------------------------------------------

 _______________________________________________________________________________



ESTIMATION OF THE FISHER INFORMATION MATRIX ____________________________________


Estimation of the Fisher information matrix by Stochastic Approximation --------

Correlation Matrix :
         ka_pop         1
beta_ka_TREAT_B  -0.39115         1
          V_pop   0.18666  -0.24624         1
 beta_V_TREAT_B  -0.20095   0.50305  -0.51687         1
         Cl_pop -0.059156  0.085545  0.035081   0.23673         1
beta_Cl_TREAT_B  0.062228  -0.15638   0.21987  -0.42177  -0.56187         1
       omega_ka 0.0094634 -0.020894-0.0044551 -0.018703 0.0082896  0.011488         1
        omega_V  0.040342  -0.13543-0.0027262 -0.084733  0.065964 0.0077397   0.20705         1
     corr1_V_Cl  -0.04921   0.14872 -0.006107  0.089186 -0.079817-0.0033188  -0.13157  -0.83509         1
       omega_Cl  0.056271   -0.1544  0.014751 -0.092802  0.078872-0.00078141   0.11783   0.78897  -0.95557         1
       gamma_ka  -0.15741   0.41327 -0.083178    0.2023  0.025753 -0.083391  -0.13256 -0.083786  0.071969 -0.074897         1
        gamma_V -0.016744  0.061833 0.0094015   0.04592 -0.087096  0.004079  -0.10661  -0.80167   0.93785  -0.89154-0.0094415         1
     corr2_V_Cl  0.067652  -0.18913   0.02285  -0.11382  0.072538  0.012732   0.12521   0.79061  -0.96306   0.94164  -0.11874  -0.90026         1
       gamma_Cl -0.054728   0.15015 -0.013524  0.090697 -0.084089 0.0025941  -0.12194  -0.79361   0.97198  -0.97321  0.067122   0.90913  -0.96104         1
              a -0.026753   0.10462 0.0077298  0.054569 -0.014295 -0.059173  -0.08949  -0.38871   0.44675  -0.41836  0.087095   0.43399  -0.41273   0.40712         1
              b  0.019825 -0.070246-0.0040322 -0.029585  0.014535  0.052811  0.044955   0.28556  -0.34013   0.31727 -0.052279  -0.33907   0.30109  -0.30996  -0.90422         1

                               min       max   max/min
Eigen values           :     0.019         6   3.2e+02

Elapsed time (seconds):      1.3
Iterations:       50 (Autostop)

 -------------------------------------------------------------------------------

 _______________________________________________________________________________



ESTIMATION OF THE LOG-LIKELIHOOD _______________________________________________

                                                            (is)
-2 x log-likelihood                       (OFV) :        1642.97
Akaike Information Criteria               (AIC) :        1674.97
Corrected Bayesian Information Criteria  (BICc) :        1720.13
Bayesian Information Criteria             (BIC) :        1711.39

Elapsed time                          (seconds) :           5.41
CPU time                              (seconds) :           5.00
MonteCarlo size (is):    10000 (Fixed number of iterations)


[Importance Sampling] Standard error        : 0.221
                      Sampling distribution : T-distribution with 5 degrees of freedom

 _______________________________________________________________________________

DATASET INFORMATION
Number of individuals: 36
Number of subjects-occasion: 72
Number of observations (Y): 720
Number of doses: 72

