
[INDIVIDUAL]
input = {ka_pop, omega_ka, V_pop, omega_V, Cl_pop, omega_Cl, gamma_pop}

DEFINITION:
ka = {distribution=logNormal, typical=ka_pop, sd=omega_ka}
V = {distribution=logNormal, typical=V_pop, sd=omega_V}
Cl = {distribution=logNormal, typical=Cl_pop, sd=omega_Cl}
gamma = {distribution=logNormal, typical=gamma_pop, no-variability}

[LONGITUDINAL]
input = {a, b}

DESCRIPTION: PK + event 


input = {ka, V, Cl, gamma, b}  

EQUATION:
Cc = pkmodel(ka, V, Cl)
h = gamma*Cc

DEFINITION:
Hemorrhaging  = {type=event, rightCensoringTime=150, hazard=h}



Concentration = {distribution=normal, prediction=Cc, errorModel=combined2(a, b)}

