
[INDIVIDUAL]
input= {ka_pop, omega_ka, V_pop, omega_V, Cl_pop, omega_Cl, gamma_pop}

DEFINITION:
ka= {distribution=lognormal, typical=ka_pop, sd=omega_ka}
V= {distribution=lognormal, typical=V_pop, sd=omega_V}
Cl= {distribution=lognormal, typical=Cl_pop, sd=omega_Cl}
gamma= {distribution=lognormal, typical=gamma_pop, no-variability}

[LONGITUDINAL]
input= {ka, V, Cl, gamma, b}

EQUATION:
Cc= pkmodel(ka, V, Cl)
h= gamma*Cc

DEFINITION:
Concentration= {type=continuous, prediction=Cc, errorModel=proportional(b)}
Hemorrhaging= {type=event, rightCensoringTime=150, hazard=h}


