********************************************************************************
*                      tisagenlecleucel_extended.mlxtran                       *
*                       at                                                     *
*                      Monolix version : 2024R1                                *
********************************************************************************


ESTIMATION OF THE POPULATION PARAMETERS ________________________________________

Fixed Effects ----------------------------     se_sa    rse(%)   P2.5_sa  P97.5_sa
foldx_pop   :                     7.25e+04  3.58e+04      49.3  3.13e+04  1.68e+05
Tmax_pop    :                         9.26     0.388      4.19      8.53      10.1
Cmax_pop    :                      2.3e+05  3.58e+04      15.6   1.7e+05   3.1e+05
alpha_pop   :                        0.146    0.0152      10.4     0.119     0.179
FB_pop      :                      0.00665  0.000987      14.8   0.00499   0.00885
beta_pop    :                      0.00487   0.00112      22.9   0.00316    0.0075
Ftoci_pop   :                         1.24    0.0549      4.43      1.14      1.35
Fster_pop   :                        0.974    0.0557      5.72     0.871      1.09

Standard Deviation of the Random Effects -
omega_foldx :                         3.15     0.375      11.9       2.5      3.97
omega_Tmax  :                        0.368    0.0318      8.65     0.311     0.436
omega_Cmax  :                          1.3      0.11      8.49       1.1      1.53
omega_alpha :                         0.86    0.0818      9.51     0.715      1.04
omega_FB    :                        0.733     0.127      17.4     0.525      1.02
omega_beta  :                        0.635     0.174      27.4     0.382      1.06

Error Model Parameters -------------------
a           :                        0.619    0.0212      3.42     0.579     0.662

Elapsed time (seconds):       39
Exploratory phase iterations:      200 (Autostop)
Smoothing phase iterations:        145 (Autostop)

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ESTIMATION OF THE INDIVIDUAL PARAMETERS ________________________________________


Estimation of the individual parameters by Conditional Distribution ------------
                  min            Q1        median            Q3           max  shrinkage(%)
foldx :           809      7.81e+04      6.27e+05      3.15e+06      1.47e+09          23.4
Tmax  :          4.78          7.35          9.44          12.2          22.1           6.4
Cmax  :      2.32e+04      1.17e+05      2.44e+05      5.16e+05      1.34e+07          7.71
alpha :        0.0204        0.0925         0.151           0.3         0.605          11.9
FB    :       0.00271       0.00618       0.00854       0.00981        0.0308          41.7
beta  :       0.00327       0.00529       0.00578       0.00645        0.0194          58.3
Ftoci :          1.24          1.24          1.24          1.24          1.24           nan
Fster :         0.974         0.974         0.974         0.974         0.974           nan

Elapsed time (seconds):       14
Iterations:      255 (Autostop)

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Estimation of the individual parameters by Conditional Mode --------------------
                  min            Q1        median            Q3           max  shrinkage(%)
foldx :           195      2.34e+04      6.97e+04      1.93e+05      7.79e+08            23
Tmax  :          4.59          7.47          9.19            12          22.2          9.76
Cmax  :      2.08e+04      1.15e+05       2.1e+05      4.73e+05      1.37e+07           8.1
alpha :        0.0212        0.0945         0.152         0.298         0.554          13.4
FB    :       0.00213       0.00497       0.00667       0.00808        0.0261          41.9
beta  :       0.00302       0.00453       0.00486       0.00524        0.0158          59.5
Ftoci :          1.24          1.24          1.24          1.24          1.24           nan
Fster :         0.974         0.974         0.974         0.974         0.974           nan

Elapsed time (seconds):      1.2

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ESTIMATION OF THE FISHER INFORMATION MATRIX ____________________________________


Estimation of the Fisher information matrix by Stochastic Approximation --------

Correlation Matrix :
  foldx_pop         1
   Tmax_pop  -0.10114         1
   Cmax_pop  0.096114  0.044427         1
  alpha_pop 0.0016288  0.067127   0.09696         1
     FB_pop  -0.10413 0.0016582  -0.12869  0.027854         1
   beta_pop -0.093797  0.038063 -0.065088  0.075255   0.48142         1
  Ftoci_pop  -0.13913-0.0058404  -0.19627 -0.029169  0.027218   0.12431         1
  Fster_pop 0.0077629  0.012391  0.049381   0.06235  0.095747  0.079224  -0.77659         1
omega_foldx  0.080384     0.021  0.032911 0.0090496 -0.046494 -0.074887 -0.066275 0.0066502         1
 omega_Tmax  0.052003  -0.13746 -0.019415 -0.010212  0.029328  0.066704  0.057661 -0.014425 -0.066182         1
 omega_Cmax 0.0018324 0.0036795 -0.026148-0.0084256-0.0023462 -0.037123 -0.044529  0.012765  0.031414-0.00033753         1
omega_alpha-0.0058011  0.031624   0.03532 -0.067114  -0.10858 -0.051651 -0.018751 -0.011907  -0.02251 -0.047136 -0.057357         1
   omega_FB -0.043535 -0.052471 -0.087355 -0.003369  0.067974   0.10217   0.10996  0.048169 -0.024539  0.086699 -0.043426 0.0070985         1
 omega_beta  0.063416  0.013049   0.11923 -0.023387  -0.20429   -0.5662  -0.34218   0.15409  0.091768  -0.12846 0.0051305  0.075558  -0.21427         1
          a -0.010655 0.0038278 0.0054031-0.0043082   0.02794  0.040843 -0.088876  0.097593 -0.062584-0.0028423 -0.021234-0.00086114 -0.084752 0.0099957         1

                               min       max   max/min
Eigen values           :      0.17       2.2        13

Elapsed time (seconds):      4.6
Iterations:       50 (Autostop)

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ESTIMATION OF THE LOG-LIKELIHOOD _______________________________________________

                                                            (is)
-2 x log-likelihood                       (OFV) :        2506.07
Akaike Information Criteria               (AIC) :        2536.07
Corrected Bayesian Information Criteria  (BICc) :        2593.63
Bayesian Information Criteria             (BIC) :        2573.57

Elapsed time                          (seconds) :          18.00
CPU time                              (seconds) :          17.00
MonteCarlo size (is):    10000 (Fixed number of iterations)


[Importance Sampling] Standard error        : 0.428
                      Sampling distribution : T-distribution with 5 degrees of freedom

 _______________________________________________________________________________

DATASET INFORMATION
Number of individuals: 90
Number of observations (LNDV): 836
Number of doses: 0

