********************************************************************************
*                          Assessment_005.mlxtran                              *
*                          July 03, 2024 at 15:04:10                           *
*                          Monolix version : 2024R1                            *
********************************************************************************


ESTIMATION OF THE POPULATION PARAMETERS ________________________________________

Fixed Effects ----------------------------     se_sa    rse(%)   P2.5_sa  P97.5_sa
foldx_pop   :                     6.09e+04  3.28e+04      53.8  2.48e+04   1.5e+05
Tmax_pop    :                         9.34     0.385      4.12      8.62      10.1
Cmax_pop    :                     2.21e+05  3.75e+04      16.9   1.6e+05  3.06e+05
alpha_pop   :                        0.146    0.0163      11.2     0.117     0.181
FB_pop      :                      0.00729   0.00124        17   0.00526    0.0101
beta_pop    :                      0.00573   0.00122      21.4   0.00382    0.0086
Ftoci_pop   :                         1.22    0.0459      3.77      1.13      1.31
Fster_pop   :                         1.05     0.095      9.01     0.884      1.26

Standard Deviation of the Random Effects -
omega_foldx :                         3.11     0.371      11.9      2.46      3.91
omega_Tmax  :                        0.361    0.0316      8.74     0.305     0.428
omega_Cmax  :                         1.31      0.12      9.15       1.1      1.56
omega_alpha :                        0.897     0.092      10.3     0.735       1.1
omega_FB    :                        0.697     0.163      23.4     0.448      1.08
omega_beta  :                        0.697     0.205      29.4     0.405       1.2

Error Model Parameters -------------------
a           :                        0.619    0.0222      3.59     0.577     0.664

Elapsed time (seconds):       37
Exploratory phase iterations:      201 (Autostop)
Smoothing phase iterations:        184 (Autostop)

 _______________________________________________________________________________



ESTIMATION OF THE INDIVIDUAL PARAMETERS ________________________________________


Estimation of the individual parameters by Conditional Distribution ------------
                  min            Q1        median            Q3           max  shrinkage(%)
foldx :           647      6.25e+04      6.05e+05      2.81e+06      4.38e+08          21.1
Tmax  :          4.98          7.28          9.75          11.9          22.2          6.41
Cmax  :      1.39e+04      1.16e+05      2.09e+05      4.96e+05      9.58e+06          8.23
alpha :        0.0208        0.0918         0.153         0.303         0.561          15.3
FB    :       0.00331       0.00689       0.00935        0.0105        0.0318            43
beta  :       0.00335       0.00579       0.00699       0.00768        0.0212          56.3
Ftoci :          1.22          1.22          1.22          1.22          1.22           nan
Fster :          1.05          1.05          1.05          1.05          1.05           nan

Elapsed time (seconds):       14
Iterations:      278 (Autostop)

 -------------------------------------------------------------------------------

 _______________________________________________________________________________



ESTIMATION OF THE FISHER INFORMATION MATRIX ____________________________________


Estimation of the Fisher information matrix by Stochastic Approximation --------

Correlation Matrix :
  foldx_pop         1
   Tmax_pop  -0.12943         1
   Cmax_pop   0.25717-0.0088333         1
  alpha_pop  0.063107  0.051985   0.13897         1
     FB_pop   0.20581 -0.044772    0.1808  0.083705         1
   beta_pop  0.053887  0.022669    0.1104   0.11759   0.39892         1
  Ftoci_pop  -0.24154  0.019067  -0.28861 -0.028913  -0.27576  -0.23562         1
  Fster_pop  -0.41439   0.09498   -0.3502 -0.053985  -0.40695  0.065342  0.031014         1
omega_foldx    0.2099 -0.012008   0.16901  0.046904   0.15628 -0.083739  -0.12741  -0.37909         1
 omega_Tmax  0.015744 -0.099855 -0.023919 -0.004123-0.0059691  0.031974  0.025596  0.065553 -0.075776         1
 omega_Cmax  0.097136 -0.022177  0.094746   0.04088   0.10425  0.026472  -0.13491   -0.1033  0.082855-0.0074462         1
omega_alpha -0.066571   0.02382 -0.069938  -0.12321  -0.10462-0.0033045   0.03391   0.12508  -0.06763 0.0088213  -0.11125         1
   omega_FB -0.076247  0.015292 -0.062638  0.099464  -0.13721   0.11341   0.15168   0.25015 -0.042776  0.027562  0.025568 -0.024436         1
 omega_beta   0.19386 -0.061354   0.13034 -0.028767   0.14041  -0.43684 -0.031713  -0.47737   0.20422 -0.030043  0.037518  0.014243  -0.30901         1
          a -0.086809-0.0023669  -0.10762 -0.085896  -0.10123 -0.026136  0.044824   0.14305  -0.12248-0.0056308 -0.081044  0.027505   -0.1954 -0.092111         1

                               min       max   max/min
Eigen values           :       0.3       2.7         9

Elapsed time (seconds):      6.3
Iterations:       68 (Autostop)

 -------------------------------------------------------------------------------

 _______________________________________________________________________________



ESTIMATION OF THE LOG-LIKELIHOOD _______________________________________________

                                                            (is)
-2 x log-likelihood                       (OFV) :        2505.97
Akaike Information Criteria               (AIC) :        2535.97
Corrected Bayesian Information Criteria  (BICc) :        2593.52
Bayesian Information Criteria             (BIC) :        2573.46

Elapsed time                          (seconds) :          26.74
CPU time                              (seconds) :          26.00
MonteCarlo size (is):    10000 (Fixed number of iterations)


[Importance Sampling] Standard error        : 0.472
                      Sampling distribution : T-distribution with 5 degrees of freedom

 _______________________________________________________________________________

DATASET INFORMATION
Number of individuals: 90
Number of observations (LNDV): 836
Number of doses: 0

