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*                          Assessment_004.mlxtran                              *
*                          July 03, 2024 at 15:02:45                           *
*                          Monolix version : 2024R1                            *
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ESTIMATION OF THE POPULATION PARAMETERS ________________________________________

Fixed Effects ----------------------------     se_sa    rse(%)   P2.5_sa  P97.5_sa
foldx_pop   :                     4.51e+04  2.11e+04      46.7  2.02e+04  1.01e+05
Tmax_pop    :                          9.4     0.396      4.22      8.65      10.2
Cmax_pop    :                     2.05e+05  3.16e+04      15.4  1.52e+05  2.76e+05
alpha_pop   :                        0.141    0.0163      11.5     0.113     0.177
FB_pop      :                      0.00607   0.00116      19.1   0.00422   0.00873
beta_pop    :                      0.00405   0.00758       187  0.000637    0.0258
Ftoci_pop   :                         1.37    0.0519      3.79      1.27      1.47
Fster_pop   :                        0.901    0.0662      7.35     0.781      1.04

Standard Deviation of the Random Effects -
omega_foldx :                         2.88     0.326      11.3      2.31      3.59
omega_Tmax  :                        0.356    0.0313      8.79       0.3     0.422
omega_Cmax  :                         1.21    0.0992      8.19      1.03      1.42
omega_alpha :                        0.848    0.0825      9.72     0.702      1.03
omega_FB    :                        0.578     0.118      20.4     0.392     0.851
omega_beta  :                        0.873     0.847      97.1     0.229      3.32

Error Model Parameters -------------------
a           :                        0.629    0.0225      3.57     0.586     0.675

Elapsed time (seconds):       33
Exploratory phase iterations:      179 (Autostop)
Smoothing phase iterations:        106 (Autostop)

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ESTIMATION OF THE INDIVIDUAL PARAMETERS ________________________________________


Estimation of the individual parameters by Conditional Distribution ------------
                  min            Q1        median            Q3           max  shrinkage(%)
foldx :           574      7.28e+04      4.81e+05      1.48e+06      7.37e+08          19.8
Tmax  :          4.95          7.09          9.44            12          21.9          3.97
Cmax  :      1.51e+04      1.11e+05      2.22e+05      4.67e+05      1.06e+07          2.65
alpha :        0.0207        0.0924          0.15         0.298          0.55          11.4
FB    :       0.00351       0.00561       0.00706       0.00828        0.0214          48.6
beta  :       0.00231       0.00439       0.00542       0.00623        0.0244          54.3
Ftoci :          1.37          1.37          1.37          1.37          1.37           nan
Fster :         0.901         0.901         0.901         0.901         0.901           nan

Elapsed time (seconds):       11
Iterations:      255 (Autostop)

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ESTIMATION OF THE FISHER INFORMATION MATRIX ____________________________________


Estimation of the Fisher information matrix by Stochastic Approximation --------

Correlation Matrix :
  foldx_pop         1
   Tmax_pop  -0.17021         1
   Cmax_pop  0.034564   0.11825         1
  alpha_pop -0.053754   0.15749   0.23733         1
     FB_pop  -0.18639    0.1605   0.16248   0.28811         1
   beta_pop  -0.15395   0.22463   0.32094   0.37263   0.71932         1
  Ftoci_pop  -0.17558   0.12833  0.080032   0.21021   0.47656   0.56286         1
  Fster_pop   0.10792  -0.15659  -0.24359  -0.24511  -0.59621  -0.69312  -0.78558         1
omega_foldx   -0.1859   0.11759  0.054125  0.066051   0.13507   0.15958   0.13114  -0.18756         1
 omega_Tmax   0.15367  -0.15668 -0.074507 -0.099037  -0.16911  -0.22543  -0.13006   0.18072  -0.17262         1
 omega_Cmax 0.0098772 0.0029763 -0.024474  0.041107  0.093868  0.040337  0.045855  -0.10303  0.027811 -0.016798         1
omega_alpha -0.042822  0.071053  0.078295 -0.018704   0.11702   0.27957   0.10569  -0.13158  0.025559 -0.081096 -0.052109         1
   omega_FB   0.15888  -0.13085  -0.10304  -0.10654   -0.3179  -0.34592  -0.23305   0.37253  -0.12925   0.13385 -0.018014 -0.098055         1
 omega_beta   0.14512  -0.21165  -0.31041  -0.35968  -0.68247  -0.97392  -0.55579   0.67962  -0.15002   0.21808 -0.037295  -0.27279   0.31202         1
          a -0.035926 -0.029774 -0.065264 -0.063246  -0.05098 -0.063264  0.016777  0.024236 -0.079202 0.0044277  -0.06357 -0.025976  -0.12196  0.063276         1

                               min       max   max/min
Eigen values           :     0.024       4.4   1.9e+02

Elapsed time (seconds):      4.5
Iterations:       58 (Autostop)

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ESTIMATION OF THE LOG-LIKELIHOOD _______________________________________________

                                                            (is)
-2 x log-likelihood                       (OFV) :        2508.88
Akaike Information Criteria               (AIC) :        2538.88
Corrected Bayesian Information Criteria  (BICc) :        2596.44
Bayesian Information Criteria             (BIC) :        2576.38

Elapsed time                          (seconds) :          17.75
CPU time                              (seconds) :          17.00
MonteCarlo size (is):    10000 (Fixed number of iterations)


[Importance Sampling] Standard error        : 0.420
                      Sampling distribution : T-distribution with 5 degrees of freedom

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DATASET INFORMATION
Number of individuals: 90
Number of observations (LNDV): 836
Number of doses: 0

