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*                          Assessment_003.mlxtran                              *
*                          July 03, 2024 at 15:01:38                           *
*                          Monolix version : 2024R1                            *
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ESTIMATION OF THE POPULATION PARAMETERS ________________________________________

Fixed Effects ----------------------------     se_sa    rse(%)   P2.5_sa  P97.5_sa
foldx_pop   :                     6.01e+04  4.31e+04      71.8  1.99e+04  1.81e+05
Tmax_pop    :                          9.4     0.387      4.11      8.67      10.2
Cmax_pop    :                     2.12e+05  4.97e+04      23.4  1.36e+05   3.3e+05
alpha_pop   :                        0.146    0.0173      11.9     0.116     0.183
FB_pop      :                      0.00685   0.00113      16.5   0.00499   0.00941
beta_pop    :                      0.00464   0.00132      28.5   0.00273   0.00788
Ftoci_pop   :                         1.25    0.0387      3.09      1.18      1.33
Fster_pop   :                         1.04     0.224      21.6     0.688      1.56

Standard Deviation of the Random Effects -
omega_foldx :                         3.02     0.331        11      2.44      3.74
omega_Tmax  :                        0.365    0.0312      8.54     0.309     0.431
omega_Cmax  :                         1.28     0.112      8.78      1.08      1.52
omega_alpha :                          0.9    0.0882       9.8     0.744      1.09
omega_FB    :                         0.62     0.169      27.2     0.374      1.03
omega_beta  :                        0.879     0.318      36.2     0.458      1.69

Error Model Parameters -------------------
a           :                        0.611    0.0252      4.13     0.564     0.663

Elapsed time (seconds):       54
Exploratory phase iterations:      302 (Autostop)
Smoothing phase iterations:        113 (Autostop)

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ESTIMATION OF THE INDIVIDUAL PARAMETERS ________________________________________


Estimation of the individual parameters by Conditional Distribution ------------
                  min            Q1        median            Q3           max  shrinkage(%)
foldx :           526      5.14e+04      4.51e+05      1.82e+06      3.72e+08          18.8
Tmax  :           4.7           7.3          9.74            12          22.1          5.78
Cmax  :      1.12e+04      1.08e+05      2.22e+05      4.77e+05      8.95e+06          6.12
alpha :        0.0193        0.0915         0.152         0.297         0.567          13.9
FB    :       0.00353       0.00631       0.00809        0.0095        0.0279          42.9
beta  :       0.00254       0.00487       0.00619       0.00737        0.0257          55.7
Ftoci :          1.25          1.25          1.25          1.25          1.25           nan
Fster :          1.04          1.04          1.04          1.04          1.04           nan

Elapsed time (seconds):      9.1
Iterations:      161 (Autostop)

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ESTIMATION OF THE FISHER INFORMATION MATRIX ____________________________________


Estimation of the Fisher information matrix by Stochastic Approximation --------

Correlation Matrix :
  foldx_pop         1
   Tmax_pop   -0.1102         1
   Cmax_pop   0.56001 -0.024124         1
  alpha_pop   0.29631  0.024257   0.37228         1
     FB_pop   0.17774-0.0019093   0.21236   0.16982         1
   beta_pop   0.13098 -0.003265   0.13478   0.14375   0.47928         1
  Ftoci_pop   0.13637-0.0078248    0.1475   0.14569   0.21757   0.22551         1
  Fster_pop  -0.67878  0.053151  -0.74332  -0.40886  -0.37353   -0.1885  -0.40417         1
omega_foldx -0.067753  0.017785  -0.11622 -0.052395   0.03065 -0.037576 -0.082659   0.14653         1
 omega_Tmax   0.15343 -0.081547   0.14353  0.068799  0.0365090.00042395  0.048708  -0.17382 -0.040647         1
 omega_Cmax     0.216 -0.015334   0.21353   0.13128   0.12066 0.0057128  0.063946  -0.30958 -0.005105  0.049689         1
omega_alpha  0.074128 0.0082758  0.079422 -0.012819-0.0030005   0.13122  0.024022 -0.086055 -0.046086-0.0038431  0.005672         1
   omega_FB  -0.20359 -0.018288   -0.2548   -0.1892  -0.45308  -0.28518  -0.20312   0.37246-0.0036233 -0.057244  -0.18888 -0.031143         1
 omega_beta  -0.14074   0.04855 -0.083815 -0.081009 -0.065051  -0.55037  -0.16051     0.124  0.089823-0.00037835  0.049693  -0.10767 -0.083191         1
          a   0.38771  -0.03751   0.42586    0.2413   0.28094   0.19274   0.23132  -0.58063  -0.12761   0.10511   0.18127  0.032213  -0.33368  -0.14227         1

                               min       max   max/min
Eigen values           :      0.14       3.8        27

Elapsed time (seconds):      4.7
Iterations:       54 (Autostop)

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ESTIMATION OF THE LOG-LIKELIHOOD _______________________________________________

                                                            (is)
-2 x log-likelihood                       (OFV) :        2508.12
Akaike Information Criteria               (AIC) :        2538.12
Corrected Bayesian Information Criteria  (BICc) :        2595.67
Bayesian Information Criteria             (BIC) :        2575.61

Elapsed time                          (seconds) :          19.32
CPU time                              (seconds) :          19.00
MonteCarlo size (is):    10000 (Fixed number of iterations)


[Importance Sampling] Standard error        : 0.464
                      Sampling distribution : T-distribution with 5 degrees of freedom

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DATASET INFORMATION
Number of individuals: 90
Number of observations (LNDV): 836
Number of doses: 0

