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*                          Assessment_002.mlxtran                              *
*                          July 03, 2024 at 15:00:10                           *
*                          Monolix version : 2024R1                            *
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ESTIMATION OF THE POPULATION PARAMETERS ________________________________________

Fixed Effects ----------------------------     se_sa    rse(%)   P2.5_sa  P97.5_sa
foldx_pop   :                     6.23e+04  2.74e+04        44  2.89e+04  1.34e+05
Tmax_pop    :                          9.4     0.391      4.16      8.67      10.2
Cmax_pop    :                     2.29e+05  3.49e+04      15.2  1.71e+05  3.08e+05
alpha_pop   :                        0.149    0.0158      10.6     0.121     0.183
FB_pop      :                      0.00636  0.000913      14.4   0.00482   0.00839
beta_pop    :                       0.0035   0.00128      36.4   0.00182   0.00675
Ftoci_pop   :                         1.27     0.063      4.97      1.15       1.4
Fster_pop   :                        0.964    0.0481      4.99     0.875      1.06

Standard Deviation of the Random Effects -
omega_foldx :                         2.85      0.32      11.2      2.29      3.54
omega_Tmax  :                        0.367     0.032       8.7      0.31     0.435
omega_Cmax  :                         1.28     0.109      8.52      1.08      1.51
omega_alpha :                        0.881    0.0866      9.83     0.728      1.07
omega_FB    :                        0.692     0.158      22.8      0.45      1.07
omega_beta  :                        0.941     0.299      31.7     0.526      1.68

Error Model Parameters -------------------
a           :                        0.612    0.0206      3.36     0.573     0.654

Elapsed time (seconds):       38
Exploratory phase iterations:      156 (Autostop)
Smoothing phase iterations:         95 (Autostop)

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ESTIMATION OF THE INDIVIDUAL PARAMETERS ________________________________________


Estimation of the individual parameters by Conditional Distribution ------------
                  min            Q1        median            Q3           max  shrinkage(%)
foldx :           745      6.04e+04      3.65e+05      1.94e+06      7.18e+08          17.5
Tmax  :           4.8          7.24           9.7          12.1            23          4.18
Cmax  :      2.08e+04      1.15e+05      2.38e+05      4.81e+05      1.47e+07          6.19
alpha :        0.0188        0.0951         0.159         0.301         0.574          13.5
FB    :       0.00323        0.0057        0.0079       0.00945        0.0307          41.4
beta  :       0.00204        0.0039       0.00501       0.00592        0.0232            59
Ftoci :          1.27          1.27          1.27          1.27          1.27           nan
Fster :         0.964         0.964         0.964         0.964         0.964           nan

Elapsed time (seconds):       10
Iterations:      182 (Autostop)

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ESTIMATION OF THE FISHER INFORMATION MATRIX ____________________________________


Estimation of the Fisher information matrix by Stochastic Approximation --------

Correlation Matrix :
  foldx_pop         1
   Tmax_pop -0.085198         1
   Cmax_pop   0.10665  0.039412         1
  alpha_pop  0.015842  0.058952   0.10732         1
     FB_pop -0.049901 -0.024475 -0.069611  0.018438         1
   beta_pop-0.0051271 -0.012543 -0.013981  0.064501   0.31318         1
  Ftoci_pop  -0.17993 -0.013437  -0.21752 -0.011579 -0.043402    0.1349         1
  Fster_pop   0.10545  0.010699   0.12772  0.028849  0.070711 -0.010408  -0.85799         1
omega_foldx  0.085773   0.04462  0.062913  0.001052  0.013598 -0.096463  -0.22837   0.14402         1
 omega_Tmax  0.052524  -0.11593-0.0092766 -0.014754  0.019169 0.0073722  0.044859 -0.037865 -0.069955         1
 omega_Cmax  0.047085-0.0018521  0.045097  0.016773 -0.008217 -0.073312   -0.1418  0.093923  0.062971  0.015376         1
omega_alpha2.6639e-05 0.0088997-0.0020091 -0.067121 -0.069275  0.027505  0.019058 -0.022475 -0.018051  -0.01104 -0.055021         1
   omega_FB   0.06783-0.0096446  0.049976  0.026582 -0.089747   0.24173 -0.036595  0.038477  -0.11441 -0.029349 -0.073364  0.029593         1
 omega_beta 0.00875330.00087319   0.01234   -0.0403 -0.013001  -0.68222 -0.091916-0.0050575    0.1124  0.026791  0.058376 -0.028888  -0.46405         1
          a -0.021571-0.0048374 -0.031836-0.0021764 -0.020653 -0.023463  0.088148 -0.082786 -0.070476 0.0047849 -0.021795 -0.025705 -0.097043-0.0062822         1

                               min       max   max/min
Eigen values           :      0.12       2.2        18

Elapsed time (seconds):      5.6
Iterations:       70 (Autostop)

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ESTIMATION OF THE LOG-LIKELIHOOD _______________________________________________

                                                            (is)
-2 x log-likelihood                       (OFV) :        2509.23
Akaike Information Criteria               (AIC) :        2539.23
Corrected Bayesian Information Criteria  (BICc) :        2596.79
Bayesian Information Criteria             (BIC) :        2576.73

Elapsed time                          (seconds) :          27.23
CPU time                              (seconds) :          27.00
MonteCarlo size (is):    10000 (Fixed number of iterations)


[Importance Sampling] Standard error        : 0.501
                      Sampling distribution : T-distribution with 5 degrees of freedom

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DATASET INFORMATION
Number of individuals: 90
Number of observations (LNDV): 836
Number of doses: 0

