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*                          Assessment_001.mlxtran                              *
*                          July 03, 2024 at 14:58:47                           *
*                          Monolix version : 2024R1                            *
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ESTIMATION OF THE POPULATION PARAMETERS ________________________________________

Fixed Effects ----------------------------     se_sa    rse(%)   P2.5_sa  P97.5_sa
foldx_pop   :                     5.55e+04  3.05e+04        55  2.22e+04  1.38e+05
Tmax_pop    :                         9.34     0.385      4.13      8.61      10.1
Cmax_pop    :                      2.1e+05  3.87e+04      18.4  1.48e+05  2.99e+05
alpha_pop   :                        0.137    0.0159      11.6      0.11     0.172
FB_pop      :                      0.00574  0.000884      15.4   0.00427   0.00772
beta_pop    :                      0.00333   0.00193      57.9   0.00129   0.00862
Ftoci_pop   :                          1.3     0.127       9.8      1.07      1.57
Fster_pop   :                        0.939     0.095      10.1     0.771      1.14

Standard Deviation of the Random Effects -
omega_foldx :                          3.1     0.422      13.6      2.39      4.04
omega_Tmax  :                        0.366    0.0323      8.82     0.308     0.434
omega_Cmax  :                         1.22     0.105      8.65      1.03      1.44
omega_alpha :                        0.907    0.0912      10.1     0.746       1.1
omega_FB    :                        0.725     0.175      24.2      0.46      1.14
omega_beta  :                        0.953     0.373      39.1     0.475      1.91

Error Model Parameters -------------------
a           :                        0.624     0.023      3.69     0.581     0.671

Elapsed time (seconds):       63
Exploratory phase iterations:      153 (Autostop)
Smoothing phase iterations:        153 (Autostop)

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ESTIMATION OF THE INDIVIDUAL PARAMETERS ________________________________________


Estimation of the individual parameters by Conditional Distribution ------------
                  min            Q1        median            Q3           max  shrinkage(%)
foldx :           565      7.47e+04      5.29e+05      2.35e+06      1.07e+09          22.1
Tmax  :          4.69          7.33          9.48          12.1          21.8          5.58
Cmax  :      2.01e+04      1.23e+05      2.29e+05      4.73e+05      1.12e+07          4.69
alpha :        0.0183        0.0928         0.148         0.293         0.577          14.1
FB    :       0.00269       0.00537       0.00742        0.0085        0.0252          45.6
beta  :       0.00207       0.00383       0.00482       0.00554        0.0247            59
Ftoci :           1.3           1.3           1.3           1.3           1.3           nan
Fster :         0.939         0.939         0.939         0.939         0.939           nan

Elapsed time (seconds):       26
Iterations:      248 (Autostop)

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ESTIMATION OF THE FISHER INFORMATION MATRIX ____________________________________


Estimation of the Fisher information matrix by Stochastic Approximation --------

Correlation Matrix :
  foldx_pop         1
   Tmax_pop -0.077037         1
   Cmax_pop   0.32984  0.044143         1
  alpha_pop  0.033262  0.060141   0.11752         1
     FB_pop  0.062892-0.0029351  0.091362   0.12177         1
   beta_pop   0.21332  0.033872   0.35494   0.19432   0.46136         1
  Ftoci_pop   -0.3813 -0.030463  -0.54991 -0.088882  -0.24303  -0.61337         1
  Fster_pop  0.028978  0.036807   0.11135   0.18656   0.19449   0.50945   -0.5997         1
omega_foldx    0.2011 0.0070183   0.30534 -0.035976   0.10624   0.21554  -0.37782 -0.067966         1
 omega_Tmax   0.01538  -0.07306 -0.041655  0.017282  0.018557-0.0048972  0.061588  0.025335 -0.095919         1
 omega_Cmax -0.013562 0.0030437 -0.055559  0.052457  0.054121  0.014894 -0.011509  0.072517-0.0072968 0.0068887         1
omega_alpha  0.038748  0.025786  0.085884  -0.11796 -0.050728   0.11262  -0.10701  0.015214  0.046556 -0.045512 -0.085031         1
   omega_FB  -0.18972 -0.029809  -0.28015   0.06991  -0.13675  -0.25691   0.47214  -0.11449    -0.312  0.077663  0.072693 -0.079758         1
 omega_beta  -0.20945 -0.024786  -0.34505  -0.16326  -0.34527  -0.85513   0.58503  -0.43871  -0.25862  0.018424 -0.026821 -0.086281   0.21633         1
          a  0.057942-0.0015654  0.096515-0.0073606  0.088888   0.25291  -0.25952    0.2125  0.044854 -0.019492 -0.063259  0.047921  -0.24442  -0.26611         1

                               min       max   max/min
Eigen values           :      0.12       3.8        31

Elapsed time (seconds):       15
Iterations:       86 (Autostop)

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ESTIMATION OF THE LOG-LIKELIHOOD _______________________________________________

                                                            (is)
-2 x log-likelihood                       (OFV) :        2507.56
Akaike Information Criteria               (AIC) :        2537.56
Corrected Bayesian Information Criteria  (BICc) :        2595.12
Bayesian Information Criteria             (BIC) :        2575.06

Elapsed time                          (seconds) :          70.65
CPU time                              (seconds) :          70.00
MonteCarlo size (is):    10000 (Fixed number of iterations)


[Importance Sampling] Standard error        : 0.482
                      Sampling distribution : T-distribution with 5 degrees of freedom

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DATASET INFORMATION
Number of individuals: 90
Number of observations (LNDV): 836
Number of doses: 0

