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*                        tisagenlecleucel_base.mlxtran                         *
*                         at                                                   *
*                        Monolix version : 2024R1                              *
********************************************************************************


ESTIMATION OF THE POPULATION PARAMETERS ________________________________________

Fixed Effects ----------------------------     se_sa    rse(%)   P2.5_sa  P97.5_sa
foldx_pop   :                     1.41e+05  7.32e+04      51.8   5.9e+04  3.39e+05
Tmax_pop    :                         9.44     0.396      4.19       8.7      10.2
Cmax_pop    :                     3.44e+05  5.85e+04        17  2.49e+05  4.77e+05
alpha_pop   :                        0.154    0.0171      11.1     0.124     0.191
FB_pop      :                      0.00563   0.00084      14.9   0.00423   0.00751
beta_pop    :                      0.00376   0.00102      27.3   0.00226   0.00625

Standard Deviation of the Random Effects -
omega_foldx :                         3.31     0.353      10.7      2.69      4.07
omega_Tmax  :                        0.366    0.0336      9.18     0.306     0.437
omega_Cmax  :                         1.48     0.121       8.2      1.26      1.74
omega_alpha :                        0.926    0.0933      10.1     0.761      1.13
omega_FB    :                        0.614     0.104      16.9     0.444      0.85
omega_beta  :                        0.922     0.177      19.2     0.639      1.33

Error Model Parameters -------------------
a           :                        0.621    0.0218       3.5      0.58     0.665

Elapsed time (seconds):       11
Exploratory phase iterations:      174 (Autostop)
Smoothing phase iterations:        157 (Autostop)

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ESTIMATION OF THE INDIVIDUAL PARAMETERS ________________________________________


Estimation of the individual parameters by Conditional Distribution ------------
                  min            Q1        median            Q3           max  shrinkage(%)
foldx :      1.04e+03      1.63e+05      1.09e+06      9.33e+06       4.1e+10          16.7
Tmax  :          4.79          7.36          9.61          12.1          21.3          7.15
Cmax  :      2.35e+04      1.49e+05      2.99e+05      6.37e+05      1.03e+08          7.65
alpha :        0.0198        0.0948         0.153         0.305          0.64          15.6
FB    :        0.0031       0.00557       0.00678       0.00778        0.0155          48.2
beta  :       0.00219       0.00432       0.00537       0.00599        0.0259          56.9

Elapsed time (seconds):       20
Iterations:      419 (Autostop)

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Estimation of the individual parameters by Conditional Mode --------------------
                  min            Q1        median            Q3           max  shrinkage(%)
foldx :           222      3.35e+04      1.37e+05      3.68e+05      1.96e+10          17.8
Tmax  :          4.55          7.49          9.18          11.8          21.7          9.08
Cmax  :      2.98e+04      1.45e+05       2.6e+05      5.99e+05      1.03e+08          8.99
alpha :        0.0208        0.0876         0.155         0.308         0.585          17.1
FB    :       0.00274       0.00471       0.00565       0.00691        0.0202          47.6
beta  :       0.00206       0.00358       0.00376       0.00452        0.0211          55.4

Elapsed time (seconds):      1.1

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ESTIMATION OF THE FISHER INFORMATION MATRIX ____________________________________


Estimation of the Fisher information matrix by Stochastic Approximation --------

Correlation Matrix :
  foldx_pop         1
   Tmax_pop  -0.11689         1
   Cmax_pop  0.054034  0.034573         1
  alpha_pop 0.0078883  0.074038   0.10129         1
     FB_pop -0.088859  0.079638  -0.05289  0.065761         1
   beta_pop -0.055356   0.11481  0.029365   0.10631    0.4958         1
omega_foldx  0.097858  0.044687  0.010611  0.035666   0.18471   0.16353         1
 omega_Tmax  0.078986  -0.129210.00045092 -0.030717  -0.10039  -0.11181  -0.10684         1
 omega_Cmax  0.022931-0.0038049   0.02715-0.0006362 0.0039989 -0.026952  0.070229  0.015492         1
omega_alpha-0.0011417 0.0053854 -0.003483 -0.033182  -0.11272 -0.025071 -0.0765110.00033517 -0.063636         1
   omega_FB  0.018923 -0.035948  0.013199 0.0033158  -0.17774  -0.12505 -0.043667  0.021821 -0.013561 -0.012503         1
 omega_beta  0.016681 -0.036755 0.0092387 -0.024433  -0.05744  -0.35081 -0.078543  0.033437-0.00025298  0.068282  -0.12512         1
          a -0.014579 -0.013205-0.0041491 -0.016029  -0.11704  -0.12419  -0.10224 -0.011156  -0.03324  0.013407 -0.081656  0.043081         1

                               min       max   max/min
Eigen values           :       0.4       1.9       4.8

Elapsed time (seconds):      2.2
Iterations:       50 (Autostop)

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ESTIMATION OF THE LOG-LIKELIHOOD _______________________________________________

                                                            (is)
-2 x log-likelihood                       (OFV) :        2539.64
Akaike Information Criteria               (AIC) :        2565.64
Corrected Bayesian Information Criteria  (BICc) :        2613.74
Bayesian Information Criteria             (BIC) :        2598.14

Elapsed time                          (seconds) :          13.63
CPU time                              (seconds) :          13.00
MonteCarlo size (is):    10000 (Fixed number of iterations)


[Importance Sampling] Standard error        : 0.467
                      Sampling distribution : T-distribution with 5 degrees of freedom

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DATASET INFORMATION
Number of individuals: 90
Number of observations (LNDV): 836
Number of doses: 0

