********************************************************************************
*         r04_warfarin_NODEs_IIV_W11b21_methodVariabFirstStage.mlxtran         *
*          at                                                                  *
*         Monolix version : 2024R1                                             *
********************************************************************************


ESTIMATION OF THE POPULATION PARAMETERS ________________________________________

Fixed Effects ----------------------------
Tlag_pop   :                         0.703
ka_pop     :                          1.02
V_pop      :                          7.93
Cl_pop     :                         0.133
R0_pop     :                          96.1
W11_pop    :                        -0.371
W12_pop    :                       -0.0435
W13_pop    :                        0.0908
W14_pop    :                        -0.441
W15_pop    :                         0.533
b11_pop    :                         0.531
b12_pop    :                         0.376
b13_pop    :                       -0.0521
b14_pop    :                        0.0955
b15_pop    :                          1.66
W21_pop    :                        -0.826
W22_pop    :                       -0.0416
W23_pop    :                         0.419
W24_pop    :                       -0.0478
W25_pop    :                        0.0569
b21_pop    :                           0.4
kout_pop   :                         0.041

Standard Deviation of the Random Effects -
omega_Tlag :                         0.576
omega_ka   :                          0.73
omega_V    :                         0.217
omega_Cl   :                         0.286
omega_R0   :                        0.0478
omega_W11  :                       2.5e-05
omega_b21  :                         0.101
omega_kout :                        0.0934

Error Model Parameters -------------------
a1         :                         0.263
b1         :                          0.05
a2         :                          3.74

Elapsed time (seconds):  5.8e+02
Exploratory phase iterations:      500 (Stopped at the maximum number of iterations/auto-stop criteria have not been reached)
Smoothing phase iterations:        200 (Stopped at the maximum number of iterations)

 _______________________________________________________________________________



ESTIMATION OF THE INDIVIDUAL PARAMETERS ________________________________________


Estimation of the individual parameters by Conditional Mode --------------------
                 min            Q1        median            Q3           max  shrinkage(%)
Tlag :         0.508          0.63         0.683         0.787          2.73          46.9
ka   :         0.283         0.917          1.04          1.18          2.63          42.2
V    :          5.04          7.06          7.97          8.96          12.4          3.33
Cl   :        0.0728         0.108         0.128         0.162         0.293        -0.755
R0   :          88.2          92.9          97.5            99           102          18.5
W11  :        -0.371        -0.371        -0.371        -0.371        -0.371          98.3
W12  :       -0.0435       -0.0435       -0.0435       -0.0435       -0.0435           nan
W13  :        0.0908        0.0908        0.0908        0.0908        0.0908           nan
W14  :        -0.441        -0.441        -0.441        -0.441        -0.441           nan
W15  :         0.533         0.533         0.533         0.533         0.533           nan
b11  :         0.531         0.531         0.531         0.531         0.531           nan
b12  :         0.376         0.376         0.376         0.376         0.376           nan
b13  :       -0.0521       -0.0521       -0.0521       -0.0521       -0.0521           nan
b14  :        0.0955        0.0955        0.0955        0.0955        0.0955           nan
b15  :          1.66          1.66          1.66          1.66          1.66           nan
W21  :        -0.826        -0.826        -0.826        -0.826        -0.826           nan
W22  :       -0.0416       -0.0416       -0.0416       -0.0416       -0.0416           nan
W23  :         0.419         0.419         0.419         0.419         0.419           nan
W24  :       -0.0478       -0.0478       -0.0478       -0.0478       -0.0478           nan
W25  :        0.0569        0.0569        0.0569        0.0569        0.0569           nan
b21  :         0.223         0.336          0.41         0.474         0.566          6.01
kout :        0.0347        0.0386        0.0409        0.0425        0.0486          22.8

Elapsed time (seconds):      2.2

 -------------------------------------------------------------------------------

 _______________________________________________________________________________



DATASET INFORMATION
Number of individuals: 32
Number of observations (obsid 1): 247
Number of observations (obsid 2): 232
Number of doses: 32

