********************************************************************************
*             r03_warfarin_NODEs_IIV_W11b21_methodNoVariab.mlxtran             *
*              at                                                              *
*             Monolix version : 2024R1                                         *
********************************************************************************


ESTIMATION OF THE POPULATION PARAMETERS ________________________________________

Fixed Effects ----------------------------
Tlag_pop   :                         0.809
ka_pop     :                           1.3
V_pop      :                          7.98
Cl_pop     :                         0.133
R0_pop     :                          96.3
W11_pop    :                        -0.322
W12_pop    :                        -0.145
W13_pop    :                         0.136
W14_pop    :                         -1.47
W15_pop    :                         0.512
b11_pop    :                         0.904
b12_pop    :                         0.524
b13_pop    :                         0.644
b14_pop    :                          2.03
b15_pop    :                          2.43
W21_pop    :                        -0.506
W22_pop    :                         0.395
W23_pop    :                         0.202
W24_pop    :                        -0.122
W25_pop    :                        0.0535
b21_pop    :                         0.286
kout_pop   :                        0.0418

Standard Deviation of the Random Effects -
omega_Tlag :                         0.539
omega_ka   :                         0.965
omega_V    :                         0.224
omega_Cl   :                         0.289
omega_R0   :                        0.0571
omega_W11  :                         0.131
omega_b21  :                        0.0769
omega_kout :                         0.093

Error Model Parameters -------------------
a1         :                         0.264
b1         :                        0.0472
a2         :                          2.96

Elapsed time (seconds):    7e+02
Exploratory phase iterations:      207 (Autostop)
Smoothing phase iterations:        112 (Autostop)

 _______________________________________________________________________________



ESTIMATION OF THE INDIVIDUAL PARAMETERS ________________________________________


Estimation of the individual parameters by Conditional Mode --------------------
                 min            Q1        median            Q3           max  shrinkage(%)
Tlag :          0.52         0.695         0.768         0.867          2.74          44.4
ka   :         0.269          1.19           1.4          1.55          3.67          45.2
V    :          5.05          7.05          8.01          8.96          12.8          3.88
Cl   :        0.0728         0.106         0.128         0.162         0.292         0.401
R0   :          86.4          92.5          98.5          99.7           104          11.3
W11  :        -0.484        -0.377        -0.307        -0.237        -0.114          27.9
W12  :        -0.145        -0.145        -0.145        -0.145        -0.145           nan
W13  :         0.136         0.136         0.136         0.136         0.136           nan
W14  :         -1.47         -1.47         -1.47         -1.47         -1.47           nan
W15  :         0.512         0.512         0.512         0.512         0.512           nan
b11  :         0.904         0.904         0.904         0.904         0.904           nan
b12  :         0.524         0.524         0.524         0.524         0.524           nan
b13  :         0.644         0.644         0.644         0.644         0.644           nan
b14  :          2.03          2.03          2.03          2.03          2.03           nan
b15  :          2.43          2.43          2.43          2.43          2.43           nan
W21  :        -0.506        -0.506        -0.506        -0.506        -0.506           nan
W22  :         0.395         0.395         0.395         0.395         0.395           nan
W23  :         0.202         0.202         0.202         0.202         0.202           nan
W24  :        -0.122        -0.122        -0.122        -0.122        -0.122           nan
W25  :        0.0535        0.0535        0.0535        0.0535        0.0535           nan
b21  :         0.133          0.23         0.282         0.335         0.386          13.9
kout :        0.0362        0.0389        0.0416        0.0435        0.0501          15.7

Elapsed time (seconds):      2.1

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 _______________________________________________________________________________



DATASET INFORMATION
Number of individuals: 32
Number of observations (obsid 1): 247
Number of observations (obsid 2): 232
Number of doses: 32

