********************************************************************************
*                     r02_warfarin_NODEs_IIV_noSA.mlxtran                      *
*                     July 15, 2024 at 17:07:55                                *
*                     Monolix version : 2024R1                                 *
********************************************************************************


ESTIMATION OF THE POPULATION PARAMETERS ________________________________________

Fixed Effects ----------------------------
Tlag_pop   :                         0.759
ka_pop     :                          1.22
V_pop      :                          7.95
Cl_pop     :                         0.132
R0_pop     :                          96.2
W11_pop    :                        -0.449
W12_pop    :                        -0.046
W13_pop    :                         0.109
W14_pop    :                        -0.612
W15_pop    :                         0.471
b11_pop    :                          0.74
b12_pop    :                         0.362
b13_pop    :                         0.349
b14_pop    :                         0.278
b15_pop    :                         0.615
W21_pop    :                        -0.573
W22_pop    :                         0.141
W23_pop    :                           0.3
W24_pop    :                        -0.029
W25_pop    :                        0.0898
b21_pop    :                         0.264
kout_pop   :                        0.0404

Standard Deviation of the Random Effects -
omega_Tlag :                         0.491
omega_ka   :                         0.777
omega_V    :                         0.218
omega_Cl   :                         0.289
omega_R0   :                        0.0507
omega_W11  :                          0.15
omega_W12  :                      6.13e-05
omega_W13  :                       8.1e-06
omega_W14  :                      4.12e-05
omega_W15  :                      0.000131
omega_b11  :                      0.000219
omega_b12  :                      0.000211
omega_b13  :                      2.37e-05
omega_b14  :                       0.00215
omega_b15  :                        0.0132
omega_W21  :                       0.00161
omega_W22  :                      0.000104
omega_W23  :                      7.12e-06
omega_W24  :                      1.99e-05
omega_W25  :                      3.75e-06
omega_b21  :                        0.0953
omega_kout :                        0.0784

Error Model Parameters -------------------
a1         :                         0.252
b1         :                        0.0518
a2         :                          3.57

Elapsed time (seconds):  1.8e+02
Exploratory phase iterations:      500 (Stopped at the maximum number of iterations/auto-stop criteria have not been reached)
Smoothing phase iterations:        157 (Autostop)

 _______________________________________________________________________________



ESTIMATION OF THE INDIVIDUAL PARAMETERS ________________________________________


Estimation of the individual parameters by Conditional Mode --------------------
                 min            Q1        median            Q3           max  shrinkage(%)
Tlag :         0.521         0.696         0.749           0.8          2.74            41
ka   :         0.274          1.11          1.31          1.45          2.86            42
V    :          5.08          7.08          8.01          8.85          12.2          3.61
Cl   :        0.0727         0.108         0.129         0.164         0.291         0.768
R0   :          87.2          92.7          97.6          99.4           102          15.3
W11  :        -0.578        -0.484        -0.451        -0.418       -0.0976          42.3
W12  :        -0.046        -0.046        -0.046        -0.046        -0.046          96.8
W13  :         0.109         0.109         0.109         0.109         0.109          96.6
W14  :        -0.612        -0.612        -0.612        -0.612        -0.612            98
W15  :         0.471         0.471         0.471         0.471         0.471          97.3
b11  :          0.74          0.74          0.74          0.74          0.74          97.3
b12  :         0.362         0.362         0.362         0.362         0.362          96.8
b13  :         0.349         0.349         0.349         0.349         0.349            98
b14  :         0.278         0.278         0.278         0.278         0.278            97
b15  :         0.614         0.615         0.615         0.616         0.616          96.9
W21  :        -0.573        -0.573        -0.573        -0.573        -0.573          96.9
W22  :          0.14         0.141         0.141         0.141         0.141          96.5
W23  :           0.3           0.3           0.3           0.3           0.3            98
W24  :        -0.029        -0.029        -0.029        -0.029        -0.029          96.4
W25  :        0.0898        0.0898        0.0898        0.0898        0.0898          98.1
b21  :        0.0832         0.196         0.266         0.332         0.415          6.67
kout :        0.0351        0.0384        0.0409        0.0419         0.047          23.1

Elapsed time (seconds):      8.5

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 _______________________________________________________________________________



DATASET INFORMATION
Number of individuals: 32
Number of observations (obsid 1): 247
Number of observations (obsid 2): 232
Number of doses: 32

