[LONGITUDINAL]
input={VMAX, KM, BIO, V2, KA, EMAX, EC50, KENZ, MTT, NN, FEMAX, FED50}

PK:
BIO_cov= BIO * (1 + FEMAX * (amtDose - 450) / (FED50 + (amtDose - 450)))

Ktr = (NN+1)/MTT
depot(target = A2, ka=KA, Ktr, Mtt=MTT, p = BIO_cov)

EQUATION:
A2_0 = 0
A3_0 = 1

CP = A2/V2

ddt_A2  = -((VMAX/(KM + CP))/V2) * A2 * A3
EFF     = (EMAX * CP) / (EC50 + CP)
ddt_A3  = KENZ * (1 + EFF) - KENZ * A3

logCP = log(CP+0.00001)

OUTPUT:
output = {logCP}